Journal List > Allergy Asthma Respir Dis > v.3(1) > 1059078

Yu: Is it necessary to put "cutoff levels of food specific IgE" in between the glass and the table in your office?

Figures and Tables

Table 1

Predictive values of food allergen-specific IgE levels*

aard-3-1-i001
Allergen Cutoff (kU/L) Diagnostic accuracy (%)
Sensitivity Specificity PPV NPV
Milk
 ≥ 2 yr 15 57 94 95 53
 < 2 yr 5 - - > 95 -
Egg
 ≥ 2 yr 7 61 95 98 38
 < 2 yr 2 - - 95 95
Peanut 14 57 100 100 36
Fish 20 25 100 100 89
Soy 30 44 94 73 82
Wheat 26 61 92 74 87

PPV, positive predictive value; NPV, negative predictive value.

*Adapted from references.2,3,4,5)

References

1. Sampson HA. Update on food allergy. J Allergy Clin Immunol. 2004; 113:805–819.
2. Boyano Martinez T, Garcia-Ara C, Diaz-Pena JM, Munoz FM, Garcia Sanchez G, Esteban MM. Validity of specific IgE antibodies in children with egg allergy. Clin Exp Allergy. 2001; 31:1464–1469.
3. Garcia-Ara C, Boyano-Martinez T, Diaz-Pena JM, Martin-Munoz F, Reche-Frutos M, Martin-Esteban M. Specific IgE levels in the diagnosis of immediate hypersensitivity to cows' milk protein in the infant. J Allergy Clin Immunol. 2001; 107:185–190.
4. Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol. 2001; 107:891–896.
5. Sampson HA, Ho DG. Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents. J Allergy Clin Immunol. 1997; 100:444–451.
6. Luyt D, Ball H, Makwana N, Green MR, Bravin K, Nasser SM, et al. BSACI guideline for the diagnosis and management of cow's milk allergy. Clin Exp Allergy. 2014; 44:642–672.
7. Clark AT, Skypala I, Leech SC, Ewan PW, Dugue P, Brathwaite N, et al. British Society for Allergy and Clinical Immunology guidelines for the management of egg allergy. Clin Exp Allergy. 2010; 40:1116–1129.
8. Du Toit G, Santos A, Roberts G, Fox AT, Smith P, Lack G. The diagnosis of IgE-mediated food allergy in childhood. Pediatr Allergy Immunol. 2009; 20:309–319.
9. Leonard SA, Sampson HA, Sicherer SH, Noone S, Moshier EL, Godbold J, et al. Dietary baked egg accelerates resolution of egg allergy in children. J Allergy Clin Immunol. 2012; 130:473–480.e1.
10. Kim JS, Nowak-Wegrzyn A, Sicherer SH, Noone S, Moshier EL, Sampson HA. Dietary baked milk accelerates the resolution of cow's milk allergy in children. J Allergy Clin Immunol. 2011; 128:125–131.e2.
11. Jhon J, Lee KE, Kim MN, Hong JY, Kim MJ, Kim YH, et al. Diagnostic utility of skin prick test to cooked egg in children with egg allergy. Allergy Asthma Respir Dis. 2015; 3:22–29.
TOOLS
Similar articles