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Kim: Occupational asthma induced by beat-galactosidase
Case Report

Allergy, Asthma & Respiratory Disease 2014; 2(1): 75-77.

Published online: 31 March 2014

DOI: https://doi.org/10.4168/aard.2014.2.1.75

Occupational asthma induced by beat-galactosidase

Mi-Kyeong Kim

Department of Internal Medicine, Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea.

Correspondence to: Mi-Kyeong Kim. Department of Internal Medicine, Medical Research Institute, Chungbuk National University College of Medicine, 410 Sunbong-ro, Heungdeok-gu, Cheongju 361-763, Korea. Tel: +82-43-269-6355, Fax: +82-43-273-3252, kimmk@chungbuk.ac.kr

Received 6 May 2013       Revised 5 July 2013       Accepted 22 July 2013

© 2014 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Galactosidase is generated from Aspergillus oryzae, which is widely used for antidiarrhea medicine to infants. Antibiotics and digestives were reported as a causative allergen inducing occupational asthma. Galatosidase-induced occupational asthma has not been reported yet. A forty-year-old female has suffered from rhinorrhea, sneezing, and nasal obstruction 1 year after handling galactosidase at obstetric and pediatric hospital, and then dyspnea appeared later. Skin prick test with inhalent allergens, beta-galactosidase, and Aspergillus oryzae showed strong positive reaction to beta-galactosidase only. Immunoinhibition test with beta-galactosidase and A. oryzae revealed inhibition to beta-galactosidase only. Bronchial provocation test with beta-galactosidase showed the dual asthmatic response. With these results, we confirmed that the patient has beta-galactosidase-induced occupational asthma and rhinitis.

Keywords: Beta-galactosidase, Occupational asthma, Immunoinhibition

Figures and Tables

Fig. 1
Results of bronchial provocation test with beta-galactosidase patient showed dual asthmatic response. FEV1, forced expiratory volume in 1 second.
aard-2-75-g001
Table 1
Results of skin prick tests with inhalant allergens, beta-galactosidase, and Aspergillus oryzae
aard-2-75-i001

Notes

This work was supported by the research grant of Chungbuk National Univesity in 2011.

References

1. Korean Society of Allergy and Immunology. Occupational asthma. Korean Society of Allergy and Immunology. Asthma and allergic disease. 2nd ed. Seoul: Yeo Moon Gak;2012. p. 286–293.
2. Oh JH, Park SW, Lee GT, Kim KU, Jeoung SW, Uh ST, et al. A case of occupational asthma induced by 7-Aminocephalosporanic acid (7-ACA). Korean J Allergy. 1997; 17:586–591.
3. Vera C, Guerrero C, Conejeros R, Illanes A. Synthesis of galacto-oligosaccharides by β-galactosidase from Aspergillus oryzae using partially dissolved and supersaturated solution of lactose. Enzyme Microb Technol. 2012; 50:188–194.
crossref
4. Kim SM, Kim KS, Kim MK. A case of anaphylaxis to trimethoprim-sulfamethoxazole. Korean J Med. 2011; 80:365–369.
5. Knuf C, Nielsen J. Aspergilli: systems biology and industrial applications. Biotechnol J. 2012; 7:1147–1155.
crossref
6. Sangwan V, Tomar SK, Singh RR, Singh AK, Ali B. Galactooligosaccharides: novel components of designer foods. J Food Sci. 2011; 76:R103–R111.
crossref
7. Peden DB, Bush RK. Advances in environmental and occupational disorders in 2012. J Allergy Clin Immunol. 2013; 131:668–674.
crossref
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