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Kim, Bae, Kim, Cho, Kwak, Kim, Son, Park, and Kim: Cause and incidence of eosinophilia in children: a single center study in one year
Original Article

Allergy, Asthma & Respiratory Disease 2014; 2(5): 358-361.

Published online: 28 November 2014

DOI: https://doi.org/10.4168/aard.2014.2.5.358

Cause and incidence of eosinophilia in children: a single center study in one year

Kyung-Min Kim, Mi-Hye Bae, Young-Mi Kim, Min-Jung Cho, Min-Jung Kwak, Seong-Heon Kim, Seung-Kook Son, Hee-Ju Park, Hye-Young Kim

Department of Pediatrics, Pusan National University School of Medicine, Busan, Korea.

Correspondence to: Hye-Young Kim. Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine, 179 Gudeok-ro, Seo-gu, Busan 602-739, Korea. Tel: +82-51-240-7298, Fax: +82-51-248-6205, ssun0@hanamil.net

Received 31 May 2014       Revised 15 September 2014       Accepted 15 September 2014

© 2014 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Purpose

Eosinophilia may be associated with various primary and reactive conditions. However, studies on the cause and incidence of eosinophilia in Korean children are rare. This study aimed to evaluate the cause and incidence of eosinophilia in patients at a single university hospital.

Methods

We studied 8,285 pediatric patients under the age of 18 years who had eosinophilia at Pusan National University Hospital. Premature and newborn infants were excluded. Eosinophilia was defined as an absolute eosinophil count greater than 450/µL. Eosinophilia was categorized as mild (450-1,500/µL), moderate (1,500-5,000/µL), and severe (>5,000/µL). The underlying conditions of eosinophilia were retrospectively investigated.

Results

Of 8,285 patients who had a hematology profile, 497 (5.9%) were found to have eosinophilia. Of patients with eosinophilia, 333 patients (67.0%) had identifiable and possible causes. The major causes of eosinophilia were allergic diseases (61.3%), infectious diseases (19.8%), immunologic diseases (9.0%) and hemato-oncologic disease (5.1%). Immunological disease such as Idiopathic hypereosinophilic syndrome, drug induced hypersensitivity syndrome and Graft-versus-host disease was the common condition with moderate to severe eosinophilia in which eosinophil count in peripheral blood was more than 1,500/µL.

Conclusion

The most common cause of eosinophilia was allergic disease. Immunological disease was the common condition with moderate to severe eosinophilia.

Keywords: Eosinophilia, Hypereosinophilia, Causes, Chilid

Figures and Tables

Table 1
Identifiable and possible causes of eosinophilia in children under the age of 18
aard-2-358-i001

SLE, systmic lupus erythematousus; JRA, juvenile idiopathic arthritis.

*No. of patients (%).†Mean±standard deviation.

Table 2
Comparison of mean eosinophil count in different clinical entitles with moderate to severe eosinophilia
aard-2-358-i002

*Mean±standard deviation.

Notes

This work was supported by clinical research grant from Pusan National University Hospital.

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