Factors associated with serum vitamin D levels in children with recurrent wheezing less than 3 years old

Eun-Jeong Choi; Nu-Ry Bag; Jin-A Jung; Dae-Cheol Kim; Hye-Sung Ahn; Hyun-Jin Yun

doi:10.4168/aard.2014.2.4.293

Journal List > Allergy Asthma Respir Dis > v.2(4) > 1059042

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Choi, Bag, Jung, Kim, Ahn, and Yun: Factors associated with serum vitamin D levels in children with recurrent wheezing less than 3 years old

Original Article

Allergy, Asthma & Respiratory Disease 2014; 2(4): 293-297.

Published online: 30 September 2014

DOI: https://doi.org/10.4168/aard.2014.2.4.293

Factors associated with serum vitamin D levels in children with recurrent wheezing less than 3 years old

Eun-Jeong Choi¹, Nu-Ry Bag², Jin-A Jung², Dae-Cheol Kim³, Hye-Sung Ahn⁴, Hyun-Jin Yun¹

¹Department of Pediatrics, Ilsin Christian Hospital, Busan, Korea.

²Department of Pediatrics, Dong-A University College of Medicine, Busan, Korea.

³Department of Pathology, Dong-A University College of Medicine, Busan, Korea.

⁴Department of Pediatrics, On Hospital, Busan, Korea.

Correspondence to: Hyun-Jin Yun. Department of Pediatrics, Ilsin Christian Hospital, 27Jeonggongdan-ro, Dong-gu, Busan 601-724, Korea. Tel: +82-51-630-0408, Fax: +82-51-630-0697, jinny198@hanmail.net

Received 31 March 2014 Revised 27 May 2014 Accepted 27 July 2014

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Purpose

We evaluated the relationship between laboratory/clinical factors and vitamin D levels in recurrent wheezers less than 3 years old.

Methods

We retrospectively analyzed clinical data and laboratory factors (25-hydroxyvitamin D, complete blood count, C-reactive protein, glutamic oxaloacetic transaminase, glutamyl purovic transaminase, alkaline phosphatase [ALP], eosinophil counts, and serum IgE IgG, IgA, IgM) of 84 children less than 3 years who had experienced wheezing episodes at least 3 times.

Results

Children in the normal group (1.4±0.9 years) were younger than those in the deficient (2.2±1.2 years) and insuffient (2.3±1.0 years) groups (P=0.010). Glutamyl purovic transaminase were higher in the normal group (24.5±19.4 IU/L) than in the deficient (16.0±4.7 IU/L) and insufficient (15.3±4.5 IU/L) groups (P=0.009). ALP were higher in the deficient (791.4±180.8 IU/L) and insufficient (770.4±251.2 IU/L) groups than in the normal group (631.9±127.0 IU/L, P=0.034). Total IgE levels were higher in the deficient group (171.9±212.1 kU/L) than in the normal group (43.7±58.3 kU/L, P<0.05), and the rate of sensitization to aeroallergens was higher in the insufficient group (36.1%) than in the normal group (10%, P<0.05).

Conclusion

Among children with recurrent wheezing less than 3 years old, low vitamin D levels may be associated with older age, total IgE, ALP level, glutamic pyruvate transaminase level, and rate of sensitization to aeroallergens.

Keywords: Vitamin D, Asthma, Wheezing, Young childhood

Figures and Tables

Table 1

Clinical characteristics of the recurrent wheezers according to the levels of 25-hydroxyvitamin D

Values are presented as mean±standard deviation or number (%).

25(OH)D, 25-hydroxyvitamin D.

Table 2

Comparisons of results of allergic tests according to the levels of 25-hydroxyvitamin D

Values are presented as mean±standard deviation or number (%) unless otherwise indicated.

^*P<0.05, compared to normal. ^†Median.

Table 3

Comparisons of results of laboratory tests according to the levels of 25-hydroxyvitamin D

Values are presented as mean±standard deviation.

WBC, white blood cell; CRP, C-reactive protein; GOT, glutamic oxalacetic transaminase; GPT, glutamic pyruvate transaminase; ALP, alkaline phosphatase.

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