Hypersensitivity reaction to aspirin accompanied by severe eosinophilia in a child with history of Kawasaki disease

In Suk Sol; Myung Hyun Choi; Min Jung Kim; Yoon Hee Kim; Hee Seon Lee; Yoon Ki Han; Ki Hwan Kim; Kyung Won Kim; Myung Hyun Sohn; Kyu-Earn Kim

doi:10.4168/aard.2014.2.2.142

Journal List > Allergy Asthma Respir Dis > v.2(2) > 1059014

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Sol, Choi, Kim, Kim, Lee, Han, Kim, Kim, Sohn, and Kim: Hypersensitivity reaction to aspirin accompanied by severe eosinophilia in a child with history of Kawasaki disease

Case Report

Allergy, Asthma & Respiratory Disease 2014; 2(2): 142-145.

Published online: 31 May 2014

DOI: https://doi.org/10.4168/aard.2014.2.2.142

Hypersensitivity reaction to aspirin accompanied by severe eosinophilia in a child with history of Kawasaki disease

In Suk Sol, Myung Hyun Choi, Min Jung Kim, Yoon Hee Kim, Hee Seon Lee, Yoon Ki Han, Ki Hwan Kim, Kyung Won Kim, Myung Hyun Sohn, Kyu-Earn Kim

Department of Pediatrics, Institute of Allergy, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.

Correspondence to: Kyu-Earn Kim. Department of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul 135-720, Korea. Tel: +82-2-2019-3353, Fax: +82-2-3461-9473, kekim@yuhs.ac

Received 4 November 2013 Revised 8 November 2013 Accepted 11 November 2013

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Drug hypersensitivity is one of drug adverse reactions that develop in susceptible patients following exposure to certain drugs and cannot be predicted from the known pharmacology of a drug. Severe hypersensitivity is associated with high morbidity and mortality. Although the issue of hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) has been largely investigated in adults, data related to NSAIDs hypersensitivity is insufficient in childhood. And in spite of the recommendation to avoid use of aspirin due to Reye syndrome in children, aspirin is one of major treatment along with intravenous immunoglobulin in Kawasaki disease. We report a case of a 10-month-old boy who underwent intravenous immunoglobulin and aspirin treatment for Kawasaki disease, and subsequently revealed severe leukocytosis and eosinophilia. To our knowledge, there have been no previous reports of aspirin-induced eosinophilia in Korea.

Keywords: Eosinophilia, Drug hypersensitivity reaction, Aspirin, Kawasaki disease

Figures and Tables

Fig. 1

Clinical course of the patient. WBC, white blood cells; EOS, eosinophil count.

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