The effect of atopy and allergic diseases on pulmonary function of Korean adolescents

Jun Won Hwangbo; Ji-Won Kwon; Ju-Hee Seo; Hyung Young Kim; Jin-Ho Yu; Hyo-Bin Kim; Woo Kyung Kim; Gwang Cheon Jang; Dae Jin Song; Jung Yeon Shim; Soo-Jong Hong; So-Yeon Lee

doi:10.4168/aard.2014.2.2.108

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Hwangbo, Kwon, Seo, Kim, Yu, Kim, Kim, Jang, Song, Shim, Hong, and Lee: The effect of atopy and allergic diseases on pulmonary function of Korean adolescents

Original Article

Allergy, Asthma & Respiratory Disease 2014; 2(2): 108-113.

Published online: 31 May 2014

DOI: https://doi.org/10.4168/aard.2014.2.2.108

The effect of atopy and allergic diseases on pulmonary function of Korean adolescents

Jun Won Hwangbo¹, Ji-Won Kwon², Ju-Hee Seo³, Hyung Young Kim⁴, Jin-Ho Yu⁵, Hyo-Bin Kim⁶, Woo Kyung Kim⁷, Gwang Cheon Jang⁸, Dae Jin Song⁹, Jung Yeon Shim¹⁰, Soo-Jong Hong⁵, So-Yeon Lee¹

¹Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

²Department of Pediatrics, Seoul National University Bungdang Hospital, Seongnam, Korea.

³Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea.

⁴Department of Pediatrics, Kosin University College of Medicine, Busan, Korea.

⁵Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

⁶Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.

⁷Department of Pediatrics, Inje University Seoul Paik Hospital, Seoul, Korea.

⁸Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.

⁹Korea University College of Medicine, Seoul, Korea.

¹⁰Department of Pediatrics, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Correspondence to: So-Yeon Lee. Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22 Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang 431-796, Korea. Tel: +82-31-380-3730, Fax: +82-31-380-3733, imipenem@hanmail.net

Received 20 August 2013 Revised 20 November 2013 Accepted 24 November 2013

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Purpose

Pulmonary function test (PFT) plays a key role in the diagnosis and management of asthma in adolescents. But, it is not clear whether adolescents with asthma have significantly reduced lung function when compared with adolescents without asthma. The purpose of this study was to determine the effect of atopy and allergic diseases on pulmonary function and bronchial hyperresponsiveness (BHR) in Korean adolescents.

Methods

A questionnaire survey was conducted on 647 middle school students (male, 264; female, 383) from Seoul city to determine the prevalence of symptoms and diagnosed allergic diseases. We also performed the PFT, methacholine challenge test, skin prick tests and serum total immunoglobulin E. Current atopic dermatitis was diagnosed by doctor's medical examination.

Results

Female showed higher values of forced expiratory volume in 1 second/forced vital capacity (FEV₁/FVC) and higher numbers of BHR (PC₂₀ less than 25 mg/dL) compared to male (P<0.01). BHR was more common in atopy group (P<0.01), but PFT was not significant difference between atopy and nonatopy. Mean values for all spirometric parameters for asthmatic adolescents were in the normal range. Adolescents with asthma symptoms had slightly lower FEV₁/FVC and forced expiratory flow 25%-75% than that of adolescents with no history of wheeze ever, asthma diagnosis and current asthma, but there was no statistically significance.

Conclusion

The majority of adolescents recruited from the general population who reported having asthma symptoms or other allergic diseases had normal lung function. Sex, atopy, and current atopic dermatitis may affect BHR in Korean adolescents.

Keywords: Pulmonary function test, Bronchial hyperresponsiveness, Asthma, Sinusitis

Figures and Tables

Table 1

Characteristics of subjects (n=643)

Values are presented as mean±standard deviation or number (%) unless otherwise indicated.

KRW, Korean won; IgE, immunoglobulin E.

Table 2

Allergic diseases and pulmonary function by sex in subjects

Values are presented as number (%) or mean±standard deviation. Chi-square test.

IgE, immunoglobulin E.

^*P-value from Student t-test.

Table 3

Allergic diseases and pulmonary function by atopy in subjects

Values are presented as number (%) or mean±standard deviation. Chi-square test.

FVC, forced vital capacity; FEV1, forced expiratory volume in 1 second; FEF_25%-75%, forced expiratory flow 25%-75%.

^*P-value from Student t-test.

Table 4

Effect of allergic diseases on the pulmonary function in adolescents

Values are presented as mean±standard deviation.

AR, allergic rhinitis; AD, atopic dermatitis.

^*Chi-square test. ^†P<0.05.

Notes

This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare, Republic of Korea (A092076).

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