The correlation between the severity of atopic dermatitis classified by SCORing atopic dermatitis index and the laboratory tests

Geun Hwa Park; Jong Ha Park; Yoon Ha Hwang; Myong Sun Sung; Sung Won Kim

doi:10.4168/aard.2013.1.1.79

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Park, Park, Hwang, Sung, and Kim: The correlation between the severity of atopic dermatitis classified by SCORing atopic dermatitis index and the laboratory tests

Original Article

Allergy, Asthma & Respiratory Disease

Allergy, Asthma & Respiratory Disease 2013; 1(1): 79-83.

Published online: 31 March 2013

DOI: https://doi.org/10.4168/aard.2013.1.1.79

The correlation between the severity of atopic dermatitis classified by SCORing atopic dermatitis index and the laboratory tests

Geun Hwa Park, Jong Ha Park, Yoon Ha Hwang, Myong Sun Sung, Sung Won Kim

Department of Pediatrics, Busan St. Mary's Medical Center, Busan, Korea.

Correspondence to: Sung Won Kim. Department of Pediatrics, Busan St. Mary's Medical Center, 25-14 Yongho-ro 232beon-gil, Nam-gu, Busan 608-838, Korea. Tel: +82-51-933-7981, Fax: +82-51-936-7531, sbdph1@paran.com

Received 30 December 2012 Revised 19 March 2013 Accepted 19 March 2013

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Purpose

SCORing atopic dermatitis (SCORAD) index is the best validated scoring system in atopic dermatitis (AD). But this scoring system has limitation to the interobserver and intraobserver variation. This study was designed to evaluate the correlation between the severity of AD classified by the SCORAD index and the laboratory tests.

Methods

We evaluated 67 children admitted in the pediatric allergy and respiratory division of Busan St. Mary's Medical Center from April 1 to 30, 2011. SCORAD index was measured by one same physician. The patients were classified into mild to moderate and severe groups by SCORAD index. We identified sex, age and family history of allergic disease. We checked laboratory tests including mycoplasma immunoglobulin (Ig) M, total IgE, eosinophil count, eosinophil cationic protein, specific IgE, total protein, albumin, IgG, IgA, IgM, IgD, and inflammatory index (lactate dehydrogenase, C-reactive protein, erythrocyte sedimentation rate) and skin culture.

Results

There were no statistically significant differences between two groups in age, sex, parental allergic history, skin culture, mycoplasma IgM, specific IgE, immunoglobulin, and inflammatory index. The SCORAD index has statistically significant positive correlations with serum total eosinophil count, and total IgE, and negative correlations with total protein, and albumin.

Conclusion

Our study suggest that serum total eosinophil count, total IgE, total protein, and albumin can be used to evaluate the severity of AD and make up for the SCORAD index.

Keywords: Atopic dermatitis, SCORAD index, Laboratory tests

Figures and Tables

Fig. 1

Correlation of SCORing atopic dermatitis (SCORAD) index with total immunoglobulin E (IgE) (A), total eosinophil count (B), eosinophil cationic protein (ECP) (C), total protein (D), albumin (E).

Table 1

Comparison of characteristics in study groups

Values are presented as number (%) or mean±standard deviation.

SCORAD, SCORing atopic dermatitis.

Table 2

Comparison of laboratory tests and skin culture in study groups

Values are presented as mean± standard deviation or number (%).

IgE, immunoglobulin E; ECP, eosinophil cationic protein; LDH, lactate dehydrogenase; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; IgM, immunoglobulin M; Others, Staphylococcus epidermidis, Enterobacter cloacae, Sterptococcus species, Enterococcus species.

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