The association between sibling and allergic rhinitis in adolescents

Ju-Hee Seo; Hyung Young Kim; Young-Ho Jung; Ji-Won Kwon; Byoung-Ju Kim; Hyo-Bin Kim; Woo Kyung Kim; So-Yeon Lee; Gwang Cheon Jang; Dae Jin Song; Jung Yeon Shim; Eun-Jin Kim; Joo-Shil Lee; Soo-Jong Hong

doi:10.4168/aard.2013.1.1.67

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Seo, Kim, Jung, Kwon, Kim, Kim, Kim, Lee, Jang, Song, Shim, Kim, Lee, and Hong: The association between sibling and allergic rhinitis in adolescents

Original Article

Allergy, Asthma & Respiratory Disease

Allergy, Asthma & Respiratory Disease 2013; 1(1): 67-72.

Published online: 31 March 2013

DOI: https://doi.org/10.4168/aard.2013.1.1.67

The association between sibling and allergic rhinitis in adolescents

Ju-Hee Seo¹, Hyung Young Kim², Young-Ho Jung³, Ji-Won Kwon⁴, Byoung-Ju Kim⁵, Hyo-Bin Kim⁶, Woo Kyung Kim⁷

, So-Yeon Lee⁸, Gwang Cheon Jang⁹, Dae Jin Song¹⁰, Jung Yeon Shim¹¹, Eun-Jin Kim¹², Joo-Shil Lee¹², Soo-Jong Hong³

¹Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea.

²Department of Pediatrics, Kosin University Gospel Hospital, Busan, Korea.

³Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

⁴Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

⁵Department of Pediatrics, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

⁶Department of Pediatrics, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

⁷Department of Pediatrics, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.

⁸Department of Pediatrics, Hallym Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

⁹Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.

¹⁰Department of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.

¹¹Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea.

¹²Department of Immunology and Pathology, Allergy TF, Korea National Institute of Health, Cheongwon, Korea.

Correspondence to: Soo-Jong Hong. Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea. Tel: +82-2-3010-3379, Fax: +82-2-473-3725, sjhong@amc.seoul.kr

Received 31 August 2012 Revised 26 February 2013 Accepted 26 February 2013

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Purpose

We investigated the effect of siblings on the development of allergic rhinitis (AR) in Korean adolescents.

Methods

A cross-sectional study of adolescents (n=3,271) aged 12 to 15 years was conducted at three middle schools in Seoul. Demographic and disease-related information was obtained through a questionnaire.

Results

The mean age of the subjects was 13.9±0.8 years comprising 48.7% males and 51.3% females. The percentage of the subjects who had ever been diagnosed with AR by physician was 30.7%. Subjects who had older sibling and who had younger sibling were 45.3% and 44.2% respectively. Subjects with older sibling were less likely to diagnose AR than subjects without older sibling (adjusted odds ratio [aOR], 0.69; 95% confidence interval [CI], 0.57 to 0.84). Subjects with older sibling, even though with family history of allergic disease had protective effect compared to subjects without older sibling (aOR, 0.62; 95% CI, 0.45 to 0.84). Subjects with younger sibling were more likely to diagnose AR than subjects without younger sibling (aOR, 1.23; 95% CI, 1.02 to 1.49).

Conclusion

These findings suggest that having older sibling is one of the important protective factor for the development of allergic rhinitis and having younger sibling is risk factor for allergic rhinitis in adolescents.

Keywords: Allergic rhinitis, Adolescent, Sibling

Figures and Tables

Table 1

General characteristics

Values are presented as number (%).

KRW, Korean Won (the currency of South Korea).

Table 2

Prevalence of allergic rhinitis

^*Allergic rhinitis symptoms during last 12 months, plus previous diagnosis by doctor.

Table 3

Analysis of allergic rhinitis diagnosis according to older, younger sibling

OR, odds ratio; CI, confidence interval.

^*Adjusted for age, sex, body mass index, exposure to tobacco smoking, family income and parental history of allergy.

Table 4

Analysis of allergic rhinitis diagnosis according to the parental allergic diseases and older sibling

OR, odds ratio; CI, confidence interval.

^*Adjusted for age, sex, body mass index, exposure to tobacco smoking and family income.

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ORCID iDs: Woo Kyung Kim
https://orcid.org/http://orcid.org/0000-0001-8730-010X
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