The differences of clinical profiles by house dust mite sensitization in patients with asthmatics in Soonchunhyang University Hospital cohort

Jung-Hyun Kim; An-Soo Jang; Shin-Ok Jeong; Young-Seok Ji; Hyun-Jung Seo; Jae-Hyung Nam; Jong-Joo Moon; Ae-Rin Baek; Jong-Sook Park; June-Hyuk Lee; Sung-Woo Park; Do-Jin Kim; Choon-Sik Park

doi:10.4168/aard.2013.1.1.50

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Kim, Jang, Jeong, Ji, Seo, Nam, Moon, Baek, Park, Lee, Park, Kim, and Park: The differences of clinical profiles by house dust mite sensitization in patients with asthmatics in Soonchunhyang University Hospital cohort

Original Article

Allergy, Asthma & Respiratory Disease

Allergy, Asthma & Respiratory Disease 2013; 1(1): 50-54.

Published online: 31 March 2013

DOI: https://doi.org/10.4168/aard.2013.1.1.50

The differences of clinical profiles by house dust mite sensitization in patients with asthmatics in Soonchunhyang University Hospital cohort

Jung-Hyun Kim, An-Soo Jang, Shin-Ok Jeong, Young-Seok Ji, Hyun-Jung Seo, Jae-Hyung Nam, Jong-Joo Moon, Ae-Rin Baek, Jong-Sook Park, June-Hyuk Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park

Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.

Correspondence to: An-Soo Jang. Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon 420-767, Korea. Tel: +82-32-621-5143, Fax: +82-32-621-6950, jas877@schmc.ac.kr

Received 19 October 2012 Revised 6 November 2012 Accepted 27 December 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Purpose

The majority of patients with allergic disease are highly sensitized to house dust mites (HDM). There is few data to observe sensitization rate to HDM in asthmatics in Korea. The aim of this study was to observe the differences of clinical profiles by HDM sensitization in patients with asthmatics in Soonchunhyang University Hospital (SCH) cohort.

Methods

We recruited 2,345 asthmatic patients in SCH cohort. Lung function, body mass index and sputum and blood eosinophils, and PC₂₀, and clinical profiles were compared by HDM sensitization.

Results

Dermatophagoides farinae (Derf) and/or Dermatophagoides pteronyssinus (Derp) (+) sensitization rate was higher prevalence in male than in female. Compared with nonatopy asthmatics, Derf and/or Derp (+) asthmatics had early onset of age [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 32.5±0.51 vs. 36.1±0.88 vs. 43.1±0.54, P<0.05]. Derf and/or Derp (+) asthmatics had shorter duration of asthma symptom than that of nonatopy asthmatics. Derf and/or Derp (+) asthmatics had lower forced expiratory volume in one second and forced vital capacity than those of Derf and Derp (-) asthmatics. PC₂₀ in Derf and/or Derp (+) asthmatics had lower than those of Derf and Derp (-) and nonatopy asthmatics [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 5.4±0.24 mg/mL vs. 6.59±0.52 mg/mL vs. 7.19±0.33 mg/mL, P<0.05]. Blood eosinophils number in Derf and/or Derp (+) asthmatics had higher than that of nonatopy asthmatics (414.7±131.1 vs. 350.6±14.0, P<0.05). Total immunoglobulin E (IgE) in Derf and/or Derp positive asthmatics had higher than that of Derf and Derp negative and nonatopy asthmatics. There was no difference of body mass index among three groups.

Conclusions

Our data indicate that atopy asthmatics sensitized to Derf and/or Derp had early onset of age, high total IgE and airway responsiveness, and eosinophilic inflammation.

Keywords: House dust mite, Atopy, Asthma, Cohort

Figures and Tables

Fig. 1

The prevalence of allergen sensitization. Derf, Dermatophagoides farinae; Derp, Dermatophagoides pteronyssinus.

Table 1

Clinical and physiologic variables in patients with bronchial asthma according to sensitization to Derf or Derp

Values are presented as mean±standard error of the mean.

Derf, Dermatophagoides farina; Derp, Dermatophagoides pteronyssinus; PC₂₀, the concentration of methacholine required to decrease the FEV₁ by 20%; FEV₁, forced expiratory volume in one second; % pred., % predicted; FVC, forced vital capacity; pys, pack-years.

^*P<0.05; Derf and/or Derp (+) compared with Derp (-) and Derf (-). ^†P<0.001; Derf and/or Derp (+) compared with Derp (-) and Derf (-). ^‡P<0.05; atopy (-) compared with Derp (+) and/or Derf (+). ^§P<0.001; atopy (-) compared with Derp (-) and Derf (-).

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ORCID iDs: Choon-Sik Park
https://orcid.org/http://orcid.org/0000-0003-2977-0255
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