Journal List > Allergy Asthma Respir Dis > v.1(4) > 1058994

Shin, Park, Yoon, Shin, Yang, Cho, Jang, Kang, Kim, Cho, Moon, and Kwon: Dapsone-induced drug reaction with eosinophilia and systemic symptoms syndrome, misdiagnosed as lymphoma


Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction with systemic manifestations. Dapsone is known to be useful for treatment of leprosy and various dermatologic conditions. We report a patient with prurigo pigmentosa who developed DRESS syndrome after dapsone treatment. She presented with lymphadenopathy, fever, eosinophilia, skin rash, and elevated liver enzymes. Initial lymph node and skin biopsy was suggestive of peripheral T-cell lymphoma. Initially, she was treated with chemotherapy. A week later after complete remission of skin symptoms, new skin lesions recurred. TCR-gene rearrangement was examined to show negative results and she was diagnosed as dapsone induced DRESS syndrome. This case emphasizes the importance of differential diagnosis of lymphoma and DRESS syndrome.

Figures and Tables

Fig. 1
Diffuse exfoliative erythroderma and maculopapular rash on patient's abdomen (A) and both arms (B).
Fig. 2
Histopathologic findings of neck lymph node biopsy (right level 1b). Lymph node biopsy showed a high proliferative activity, immunohistochemistry results suggestive of peripheral T-cell lymphoma. Diffuse polymorphic lymphoid hyperplasia with effacement of the normal lymphoid follicle architecture: (A) H&E, ×40; (B) H&E, ×400; (C) CD3, positive; (D) CD4, positive; (E) CD7, negative; (F) CD8, negative; (G) Ki-67, labeling index 70%; (H) TIA-1, negative.
Fig. 3
Biopsy of back skin with recurred skin eruption at second admission. Histological examination of the skin showed lymphocytic infiltration in the epidermis, and perivascular lymphocytic infiltration in the dermis. Epidermotropism is not identified (A, B: H&E, ×400). Similar immunohistochemistry findings with lymph node was observed (C: CD3, positive; D: CD4, positive; E: CD7, negative; F: Ki-67, 80%).
Fig. 4
Pictures of recurred skin eruption at second admission. Diffuse exfoliative erythroderma and maculopapular rash on patient's hands (A, B), abdomen (C), and back (D).
Fig. 5
Biopsy of wrist skin with recurred skin eruption at second admission. Histological examination of the skin revealed spongiosis and basal vacuolar degeneration with perivascular lymphocytic infiltration, consistent with a drug-associated eruption (A, B: H&E, ×400).


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