Characteristics between IgE mediated and non-IgE mediated atopic dermatitis in children

Hyung Su Kim; Ji-In Jung; Sun Bok Suh; Jin-A Jung

doi:10.4168/aard.2013.1.4.339

Journal List > Allergy Asthma Respir Dis > v.1(4) > 1058981

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Kim, Jung, Suh, and Jung: Characteristics between IgE mediated and non-IgE mediated atopic dermatitis in children

Original Article

Allergy, Asthma & Respiratory Disease 2013; 1(4): 339-343.

Published online: 31 December 2013

DOI: https://doi.org/10.4168/aard.2013.1.4.339

Characteristics between IgE mediated and non-IgE mediated atopic dermatitis in children

Hyung Su Kim¹, Ji-In Jung², Sun Bok Suh¹, Jin-A Jung²

¹Department of Pediatrics, Busan Medical Center, Busan, Korea.

²Department of Pediatrics, Dong-A University College of Medicine, Busan, Korea.

Correspondence to: Jin-A Jung. Department of Pediatrics, Dong-A University College of Medicine, 32 Daesingongwon-ro, Seo-gu, Busan 602-714, Korea. Tel: +82-51-240-5617, Fax: +82-51-242-2765, jina1477@dau.ac.kr

Received 6 May 2013 Revised 26 August 2013 Accepted 7 September 2013

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Purpose

Atopic dermatitis (AD) is a chronic inflammatory skin disorder with a association of genetic, environmental, and immunologic factors in the development of AD. And AD can be classified into IgE mediated and non-IgE mediated. We investigated a difference of clinical characteristics and immune response between the two groups.

Methods

From January 2008 to December 2011, we enrolled 125 children who visited Dong-A University Medical Center and Busan Medical Center, and were diagnosed as AD with the Haniffin and Rajka's criteria. We checked the history of combined asthma and allergic rhinitis and allergic disease of family in patients. We measured serum total IgE, specific IgE by ImmunoCAP or skin prick test. We measured serum interleukin (IL) 4 (IL-4), interferon-γ (IFN-γ), IL-10, and IL-17, which are associated with chronic inflammatory disorder by flow cytometry method (Luminex).

Results

Eighty (64%) were included in the IgE mediated group, while forty-five (36%) were included in the non-IgE mediated group. The frequency of combined allergic disorder and serum total eosinophil count were relatively higher in IgE mediated group (P=0.023, P=0.032). The incidence of a family history in allergic disease and the mean of SCORing Atopic Dermatitis index had no difference between the two groups. Serum IL-4, IFN-γ, IL-10, IL-17 were higher in the IgE mediated group, but there were no statistically significant differences between two groups (P>0.05).

Conclusion

IgE mediated AD showed higher total eosinophil count and higher incidence of bronchial asthma and allergic rhinitis than non IgE mediated AD.

Keywords: Atopic dermatitis, Immunoglobulin E, IL-4, IFN-γ, IL-10, IL-17

Figures and Tables

Table 1

Characteristics of the patients

Values are presented as median (95% confidence interval) unless otherwise indicated.

^*By t-test between 2 groups.

Table 2

Combined allergic diseases of the patients and family

^*By Fischer exact test between 2 groups. ^†By Pearson chi-square test between 2 groups.

Table 3

Sensitization rates to common allergens

Dp, Dermatophagoides pteronyssinus; Df, Dermatophagoides farinae.

Table 4

Serum cytokine levels in IgE and non-groups

Values are presented as median (95% confidence interval).

IL, interleukin; INF, interferon.

Notes

This study was supported by Dong-A University research funds and a grant from Busan Medical Center.

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