The safety of influenza vaccination in children with egg allergy

Soo Jin Chang; In Suk Sol; Yoon Hee Kim; Hee Seon Lee; Yoon Ki Han; Hyun Bin Park; Min Jung Kim; Kyung Won Kim; Myung Hyun Sohn; Kyu-Earn Kim

doi:10.4168/aard.2013.1.4.333

Journal List > Allergy Asthma Respir Dis > v.1(4) > 1058980

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Chang, Sol, Kim, Lee, Han, Park, Kim, Kim, Sohn, and Kim: The safety of influenza vaccination in children with egg allergy

Original Article

Allergy, Asthma & Respiratory Disease 2013; 1(4): 333-338.

Published online: 31 December 2013

DOI: https://doi.org/10.4168/aard.2013.1.4.333

The safety of influenza vaccination in children with egg allergy

Soo Jin Chang, In Suk Sol, Yoon Hee Kim, Hee Seon Lee, Yoon Ki Han, Hyun Bin Park, Min Jung Kim, Kyung Won Kim, Myung Hyun Sohn, Kyu-Earn Kim

Department of Pediatrics, Institute of Allergy, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.

Correspondence to: Min Jung Kim. Department of Pediatrics, Institute of Allergy, Severance Children's Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. Tel: +82-2-2228-2050, Fax: +82-2-393-9118, mj1217@yuhs.ac

Received 5 June 2013 Revised 2 August 2013 Accepted 9 August 2013

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Purpose

Although influenza vaccine contains some residual egg protein (ovalbumin), recent studies have been reported that the influenza vaccine is even safe for patients with egg allergy. The object of this study was to assess the safety of influenza vaccination and estimate the risk factors of allergic reactions to influenza vaccination in children with egg allergy.

Methods

The medical records of 108 children were reviewed retrospectively, those were diagnosed as egg allergy at Department of Pediatrics in Severance Children's Hospital between January 2006 and December 2011. All of them were vaccinated with very low ovalbumin concentration (≤0.12 µg/mL). Patients were vaccinated in graded doses by the international guideline. Subjects without allergic reactions to influenza vaccine among egg allergy patients were recruited as control subjects.

Results

Only 12 subjects of patients had adverse reactions to influenza vaccination. There were no significant relationships between adverse reactions to influenza vaccine and their own history of other allergy, history of breast feeding or graded vaccination. The egg allergy symptoms or egg-specific IgE levels were not associated with adverse reactions to influenza vaccination.

Conclusion

These results show that patients with egg allergy may have adverse reactions with influenza vaccine, but severe adverse reactions are rare as general population. Therefore, the patients with egg allergy can be safe vaccinated with influenza vaccine, regardless of severity of allergic reaction after egg ingestion or methods of vaccination.

Keywords: Egg hypersensitivity, Influenza, Vaccination, Ovalbumin

Figures and Tables

Table 1

Characteristics of patients with egg allergy (n=108)

Values are presented as number (%) unless otherwise indicated.

SD, standard deviation.

Table 2

Symptoms of patients with adverse reaction to influenza vaccination (n=12)

Table 3

Comparison between patients without adverse reaction and with adverse reaction to influenza vaccination

Values are presented as mean±standard deviation, number (%), or median (range).

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