Increased serum surfactant protein-D in the infants with acute respiratory syncytial virus bronchiolitis

Mi Ae Chu; Eun Joo Lee; Hye Jin Park; Kye Hyang Lee; Woo Taek Kim; Hai Lee Chung

doi:10.4168/aard.2013.1.3.235

Journal List > Allergy Asthma Respir Dis > v.1(3) > 1058964

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Chu, Lee, Park, Lee, Kim, and Chung: Increased serum surfactant protein-D in the infants with acute respiratory syncytial virus bronchiolitis

Original Article

Allergy, Asthma & Respiratory Disease 2013; 1(3): 235-240.

Published online: 30 September 2013

DOI: https://doi.org/10.4168/aard.2013.1.3.235

Increased serum surfactant protein-D in the infants with acute respiratory syncytial virus bronchiolitis

Mi Ae Chu, Eun Joo Lee, Hye Jin Park, Kye Hyang Lee, Woo Taek Kim, Hai Lee Chung

Department of Pediatrics, Catholic University of Daegu School of Medicine, Daegu, Korea.

Correspondence to: Hai Lee Chung. Department of Pediatrics, Catholic University of Daegu School of Medicine, Duryugongwon-ro 17-gil, Nam-gu, Daegu 705-718, Korea. Tel: +82-53-650-4245, Fax: +82-53-622-4240, hlchung@cu.ac.kr

Received 30 March 2013 Revised 10 August 2013 Accepted 11 August 2013

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).

Abstract

Purpose

Collectin family is an important component of innate immunity, of which surfactant protein (SP)-D and mannose-binding lectin (MBL) are the most characterized. We examined SP-D and MBL in young children with acute respiratory syncytial virus (RSV) bronchiolitis.

Methods

Sixty-three children (≤24 months of age) admitted with the first RSV bronchiolitis during 2 epidemics and followed for 1 year after discharge were enrolled. The patients were defined as severe group when they had 2 of followings during admission: hypoxemia (<92% oxygen saturation), rapid breathing (and/or lower chest wall indrawing), and >7 days of hospital stay. All children were evaluated if they had recurrent wheezing during follow-up. SP-D and MBL were measured using enzyme-linked immunosorbent assay in serum collected on admission and compared with controls. Their levels were evaluated in relation to the symptom severity during admission and recurrence of wheezing after discharge.

Results

Serum SP-D increased significantly in the patients (P<0.01), but MBL showed no difference compared to the controls. SP-D levels were significantly higher in severe group compared with nonsevere group (P<0.05). SP-D levels in the patients with recurrent wheezing after discharge were significantly higher than in those without (P<0.05). MBL showed no difference in relation to the symptom severity or recurrence of wheezing.

Conclusion

Our study showed that serum SP-D was associated with the severity of RSV bronchiolitis and suggests that it might be a biomarker of lung injury and recurrence of wheezing illnesses in the young children admitted with their first RSV bronchiolitis.

Keywords: Surfactant protein-D, Mannose-binding lectin, Respiratory syncytial virus, Bronchiolitis

Figures and Tables

Table 1

Clinical characteristics of the patients and controls

Values are presented as mean±standard deviation, number (%), or median (interquartile range).

NA, not applicable; IgE, immunoglobulin E;.ND, not done.

^*Interval between symptom onset and serum sampling for surfactant protein D and mannose-binding lectin.

Table 2

Serum SP-D and MBL levels in patients and controls

Values are presented as mean±standard deviation.

SP-D, surfactant protein D; MBL, mannose-binding lectin.

Table 3

Demographic findings and serum SP-D and MBL levels in severe vs. nonsevere group

Values are presented as mean±standard deviation, number (%), or median (interquartile range).

SP-D, surfactant protein D; MBL, mannose-binding lectin; WBC, white blood cell; IgE, immunoglobulin E.

^*≥1 Positive allergen-specific IgE in ImmunoCAP or skin prick test.

Table 4

Demographic findings and serum SP-D and MBL levels in the patients with vs. without recurrent wheezing

Values are presented as mean±standard deviation, number (%), or median (interquartile range).

SP-D, surfactant protein D; MBL, mannose-binding lectin; IgE, immunoglobulin E.

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