Journal List > Korean J Neurotrauma > v.9(2) > 1058933

Kim, Cheong, Lee, Kim, and Kim: Clinical Experiences of Unruptured Vertebral Artery Dissection

Abstract

Objective

The natural course of unruptured vertebral artery dissection remains unclear. The clinical manifestation of unruptured vertebral artery dissection varies from headache, focal neurologic deficits caused by ischemia to subarachnoid hemorrhage with high mortality. The purpose of this study is to investigate the clinical course of unruptured vertebral artery dissection.

Methods

From March 2011 to April 2013, 7 patients with headache or nuchal pain by spontaneous vertebral artery dissection visited our institute were retrospectively reviewed. Their clinical data was obtained by medical records and radiologic studies including computed tomographic angiography, magnetic resonance imaging, magnetic resonance angiography and digital subtraction angiography.

Results

No patient experienced fatal outcome by subarachnoid hemorrhage or vertebrobasilar ischemia during follow-up period. Radiologic studies also did not show the evidence of subarachnoid hemorrhage or vertebrobasilar ischemia. Followup angiography showed the decreased size or disappearance of aneurysm in 3 patients.

Conclusion

This study suggests that the natural course of unruptured vertebral artery dissection is not aggressive. Patients with unruptured vertebral artery dissection could be managed with conservative treatment including anticoagulants and/or antiplatelet agents.

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FIGURE 1.
Case 2. A 54-year-old woman with intermittent headache after swimming. A: Initial CTA showing fusiform aneurysm at left V4 segment. B: After 4 months, the aneurysm disappeared completely. CTA: computed tomographic angiography.
kjn-9-69f1.tif
FIGURE 2.
Case 4. A 56-year-old male with headache after a physical fight. A: Initial CTA showing fusiform aneurysm at left distal vertebral artery. B: After 5 months, increase in size and change in shape of the aneurysm from fusiform to globular. C: One month later, size of the aneurysm decreased reversely and its shape changed from globular to fusiform. D: The recent CTA, aneurysm became smaller. CTA: computed tomographic angiography.
kjn-9-69f2.tif
TABLE 1.
Clinical characteristics of the patients and location and shape of aneurysm
Case no. Age Sex Presentation Onset (days ago) Cause Location of aneurysm Shape of aneurysm Co-morbidity SAH F/U period (mos)
1 44 M Headache 3 Sit up Left V4 distal VA Fusiform   6
2 54 F Headache 7 Swimming Left V4 FusiformFalse lumen   8
3 38 M Headache 7 Coitus Left distal VA Fusiform   24
4 56 M Headache 10 Fight Left distal VA Globular to fusiform Circumferential enhanced-plaque HT, smoking 22
5 74 F Headache 2 Sudden attack Left PICA Saccular with daughter sacWide neck   1
6 75 F Nuchal pain 7 Sudden attack Left proximal PICA Dumbbell-shaped, bilobular   11
7 38 F Headache 3 Sudden attack Rt. V4 Fusiform   1

M: male, F: female, VA: vertebral artery, V4: V4 segment of vertebral artery, PICA: posterior inferior cerebellar artery, SAH: subarachnoid hemorrhage, HT: hypertension, mos:months

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