Journal List > Korean J Neurotrauma > v.8(2) > 1058884

Factors Affecting Postoperative Recurrence of Chronic Subdural Hematoma

Abstract

Objective:

Considerable recurrence rates have been reported for chronic subdural hematoma (CSDH) following surgical evacuation. The aim of this study was to determine the independent factors and features of CSDH that are associated with postoperative recurrence.

Methods:

Retrospective analysis of 136 consecutive patients diagnosed with CSDH who were surgically treated from September 2005 to December 2011 was performed. The demographic data, clinical characteristics, radiologic features were analyzed to clarify the correlation between independent variables and postoperative recurrence of CSDH.

Results:

CSDH was resolved within 1 month following surgery in 51 patients (37.5%), between 1 to 3 months in 59 patients (43.4%), and past 3 months in 14 patients (10.3%). A total of 12 patients (8.8%) experienced recurrence of CSDH, and reoperation was performed in all recurred cases. The average duration between initial surgery and reoperation was 20.1 days. Delayed resolution and recurrence were more commonly presented in bilateral CSDH, but this data was not statistically significant. Large hematomas with maximum thickness over 20 mm were significantly correlated with higher recurrence rates of CSDH (p=0.032). In addition, the incidence of recurrence was significantly higher in the cases with high-density and mixed-density hematomas according to brain computed tomography (CT) findings (p=0.0026).

Conclusion:

The thickness and density of the hematoma is significantly correlated with higher recurrence rates of CSDH. Discerning these risk factors could be beneficial in predicting the postoperative recurrence of CSDH.

REFERENCES

1). Amirjamshidi A., Abouzari M., Eftekhar B., Rashidi A., Rezaii J., Esfandiari K, et al. Outcomes and recurrence rates in chronic subdural haematoma. Br J Neurosurg. 21:272–275. 2007.
crossref
2). Choi CH., Moon BG., Kang HI., Lee SJ., Kim JS. Factors affecting the reaccumulation of chronic subdural hematoma after burr-hole trephination and closed-system drainage. J Korean Neurosurg Soc. 35:192–198. 2004.
3). Choi WW., Kim KH. Prognostic factors of chronic subdural hematoma. J Korean Neurosurg Soc. 32:18–22. 2002.
4). Cousseau DH., Echevarría Martín G., Gaspari M., Gonorazky SE. [Chronic and subacute subdural haematoma. An epidemiological study in a captive population]. Rev Neurol. 32:821–824. 2001.
5). El-Kadi H., Miele VJ., Kaufman HH. Prognosis of chronic subdural hematomas. Neurosurg Clin N Am. 11:553–567. 2000.
crossref
6). Friede RL., Schachenmayr W. The origin ofsubdural neomembranes. II. Fine structural of neomembranes. Am J Pathol. 92:69–84. 1978.
7). Jeong CA., Kim TW., Park KH., Chi MP., Kim JO., Kim JC. Retrospective analysis of re-operated patients after chronic subdural hematoma surgery. J Korean Neurosurg Soc. 38:116–120. 2005.
8). Jeong JE., Kim GK., Park JT., Lim YJ., Kim TS., Rhee BA, et al. A clinical analysis of chronic subdural hematoma according to age factor. J Korean Neurosurg Soc. 29:748–753. 2000.
9). Kang MS., Koh HS., Kwon HJ., Choi SW., Kim SH., Youm JY. Factors influencing recurrent chronic subdural hematoma after surgery. J Korean Neurosurg Soc. 41:11–15. 2007.
10). Kim HY., Kwon SC., Kim TH., Shin HS., Hwang YS., Park SK. Analysis of management according to CT findings in chronic subdural hematoma. J Korean Neurosurg Soc. 37:96–100. 2005.
11). Ko BS., Lee JK., Seo BR., Moon SJ., Kim JH., Kim SH. Clinical analysis of risk factors related to recurrent chronic subdural hematoma. J Korean Neurosurg Soc. 43:11–15. 2008.
crossref
12). Kravtchouk AD., Likhterman LB., Potapov AA., El-Kadi H. Postoperative complications of chronic subdural hematomas: prevention and treatment. Neurosurg Clin N Am. 11:547–552. 2000.
13). Kurokawa Y., Ishizaki E., Inaba K. Bilateral chronic subdural hematoma cases showing rapid and progressive aggravation. Surg Neurol. 64:444–449. discussion 449. 2005.
crossref
14). Lee KS., Bae WK., Yoon SM., Doh JW., Bae HG., Yun IG. Location of the chronic subdural haematoma: role of the gravity and cranial morphology. Brain Inj. 15:47–52. 2001.
crossref
15). Lind CR., Lind CJ., Mee EW. Reduction in the number of repeated operations for the treatment of subacute and chronic subdural hematomas by placement of subdural drains. J Neurosurg. 99:44–46. 2003.
crossref
16). Mori K., Maeda M. Surgical treatment of chronic subdural hematoma in 500 consecutive cases: clinical characteristics, surgical outcome, complications, and recurrence rate. Neurol Med Chir (Tokyo). 41:371–381. 2001.
crossref
17). Nakaguchi H., Tanishima T., Yoshimasu N. Factors in the natural history of chronic subdural hematomas that influence their postoperative recurrence. J Neurosurg. 95:256–262. 2001.
crossref
18). Nomura S., Kashiwagi S., Fujisawa H., Ito H., Nakamura K. Characterization of local hyperfibrinolysis in chronic subdural hematomas by SDS-PAGE and immunoblot. J Neurosurg. 81:910–913. 1994.
crossref
19). Okada Y., Akai T., Okamoto K., Iida T., Takata H., Iizuka H. A comparative study of the treatment of chronic subdural hematoma—burr hole drainage versus burr hole irrigation. Surg Neurol. 57:405–409. discussion 410. 2002.
crossref
20). Ramachandran R., Hegde T. Chronic subdural hematomas—causes of morbidity and mortality. Surg Neurol. 67:367–372. discussion 372-373, 200.
crossref
21). Santarius T., Kirkpatrick PJ., Ganesan D., Chia HL., Jalloh I., Smielews-ki P, et al. Use of drains versus no drains after burr-hole evacuation of chronic subdural haematoma: a randomised controlled trial. Lancet. 374:1067–1073. 2009.
crossref
22). Son WS., Park SH., Kang DH., Park J., Sung JK., Hwang SK. Relationship between the level of fibrinogen and the signal density on brain computed tomography in the chronic subdural hematoma. J Korean Neurotraumatol Soc. 6:43–47. 2010.
crossref
23). Stanisic M., Lund-Johansen M., Mahesparan R. Treatment of chronic subdural hematoma by burr-hole craniostomy in adults: influence of some factors on postoperative recurrence. Acta Neurochir (Wien). 147:1249–1256. discussion 1256-1257. 2005.
crossref
24). Stroobandt G., Fransen P., Thauvoy C., Menard E. Pathogenetic factors in chronic subdural haematoma and causes of recurrence after drainage. Acta Neurochir (Wien). 137:6–14. 1995.
crossref
25). Tanikawa M., Mase M., Yamada K., Yamashita N., Matsumoto T., Banno T, et al. Surgical treatment of chronic subdural hematoma based on intrahematomal membrane structure on MRI. Acta Neurochir (Wien). 143:613–618. discussion 618-619. 2001.
crossref
26). Taussky P., Fandino J., Landolt H. Number of burr holes as independent predictor of postoperative recurrence in chronic subdural haematoma. Br J Neurosurg. 22:279–282. 2008.
crossref
27). Torihashi K., Sadamasa N., Yoshida K., Narumi O., Chin M., Yamagata S. Independent predictors for recurrence of chronic subdural hematoma: a review of 343 consecutive surgical cases. Neurosurgery. 63:1125–1129. discussion 1129. 2008.
28). Tsutsumi K., Maeda K., Iijima A., Usui M., Okada Y., Kirino T. The relationship of preoperative magnetic resonance imaging findings and closed system drainage in the recurrence of chronic subdural hematoma. J Neurosurg. 87:870–875. 1997.
crossref
29). Wilberger JE. Pathophysiology of evolution and recurrence of chronic subdural hematoma. Neurosurg Clin N Am. 11:435–438. 2000.
crossref
30). Yamamoto H., Hirashima Y., Hamada H., Hayashi N., Origasa H., Endo S. Independent predictors of recurrence of chronic subdural hematoma: results of multivariate analysis performed using a logistic regression model. J Neurosurg. 98:1217–1221. 2003.
crossref

TABLE 1.
Demographic characteristics and clinical findings of the patients in the recurred group and the group with no recurrence
Variables Number of patients (%) p value
RG NRG Total
Gender       0.794
Male 07 (58.3) 091 (73.4) 098 (72.1)  
Female 05 (41.7) 033 (26.6) 038 (27.9)  
Mean age (years) 62.3 67.1 64.3 0.912
Mental status       0.371
Alert 07 (58.3) 085 (68.6) 092 (67.6)  
Confused 02 (16.7) 020 (16.2) 022 (16.2)  
Drowsy 02 (16.7) 014 (11.6) 016 (11.8)  
Stuporous 01 (8.3) 004 (3.4) 005 (3.7)  
Comatose 00 (0.0) 001 (0.2) 001 (0.7)  
History of head       0.469
trauma        
Present 10 (83.3) 095 (76.6) 105 (77.2)  
Absent 02 (16.7) 029 (23.4) 031 (22.8)  
History of seizure       0.702
Present 01 (8.3) 004 (3.2) 005 (3.7)  
Absent 11 (91.7) 120 (96.8) 131 (96.3)  

RG: recurrence group, NRG: nonrecurrence group

TABLE 2.
The risk factors in 136 patients with chronic subdural hematoma
Risk factor Number of patients (%) p value
RG NRG Total
Chronic alcoholism       0.274
Present 07 (58.3) 046 (37.1) 053 (38.9)  
Absent 05 (41.7) 078 (62.9) 083 (61.1)  
Smoking       0.713
Present 03 (25.0) 041 (33.1) 044 (32.4)  
Absent 09 (75.0) 083 (66.9) 092 (67.6)  
Hypertension       0.625
Present 04 (33.3) 043 (34.7) 047 (34.6)  
Absent 08 (66.7) 081 (65.3) 089 (65.4)  
Cardiovascular       0.742
disease        
Present 02 (16.7) 015 (12.1) 017 (12.5)  
Absent 10 (83.3) 109 (87.9) 119 (87.5)  
Cerebrovascular disease       0.216
Present 03 (25.0) 023 (18.5) 026 (19.1)  
Absent 09 (75.0) 101 (81.5) 110 (80.9)  
Prolongation of       0.721
PT INR or aPTT        
Present 02 (16.7) 016 (12.9) 018 (13.2)  
Absent 10 (83.3) 108 (87.1) 118 (86.8)  
Antiplatelet or       0.758
anticoagulant        
On medication 1 (8.3) 014 (11.3) 015 (11.0)  
Not on 11 (91.7) 110 (88.7) 121 (89.0)  
medication        

RG: recurrence group, NRG: nonrecurrence group

TABLE 3.
Preoperative radiologic features of chronic subdural hematoma on brain computed tomography
Radiologic features Number of patients (%) p value
RG NRG Total
Laterality       0.4530
Right 3 (25.0) 37 (29.8) 40 (29.4)  
Left 7 (58.3) 68 (54.8) 75 (55.1)  
Bilateral 2 (16.7) 19 (15.4) 21 (15.4)  
Thickness       0.0320
<20 mm 4 (33.3) 76 (61.3) 80 (58.8)  
≥20 mm 8 (66.7) 48 (38.7) 56 (41.2)  
Density       0.0026
High 4 (33.3) 11 (8.9)0 15 (11.0)  
Mixed 5 (41.7) 24 (19.4) 29 (21.3)  
Iso 2 (16.7) 61 (19.2) 63 (46.3)  
Low 1 (8.3)0 28 (22.5) 29 (21.3)  

RG: recurrence group, NRG: nonrecurrence group

TABLE 4.
Comparison of recurrence rates in patients treated with one burr hole vs. two burr holes
Factors OBH TBH p value
No. of patients 32 (23.5%) 104 (76.5%)  
Recurrence 01 (3.1%)0 011 (10.6%) 0.175

OBH: one burr hole, TBH: two burr holes

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