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Lee and Kang: ABO-Incompatible Kidney Transplantation
Review Article

The Ewha Medical Journal 2015; 38(1): 7-13.

Published online: 26 March 2015

DOI: https://doi.org/10.12771/emj.2015.38.1.7

ABO-Incompatible Kidney Transplantation

Shina Lee, Duk-Hee Kang

Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.

Corresponding author Duk-Hee Kang. Department of Internal Medicine, Ewha Womans University School of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 158-710, Korea. Tel: 82-2-2650-5132, Fax: 82-2-2650-2505, dhkang@ewha.ac.kr

Received 11 February 2015       Accepted 16 February 2015

Copyright © 2015, The Ewha Medical Journal

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Kidney transplantation is the best treatment for end-stage renal disease patients. However, the relative shortage of organs for transplantation has led to ABO-incompatible kidney transplantation as an accepted method to expand the pool of kidney donors. Recent advances in immunosuppression and antibody removal methods have made ABO-incompatible kidney transplantation more feasible, and have increased the opportunities for patients to receive kidney transplantation, as well as for special patients with ABO-compatible donor. Indeed, the outcome of ABO-incompatible kidney transplantation has shown remarkable developments and is now comparable to that of ABO-compatible kidney transplantation during last decade. However, there are still some uncertain issues to be addressed in ABO-incompatible kidney transplantation. In this article, we reviewed the current status and protocol of ABO-incompatible kidney transplantation and listed the concerns to be addressed in near future.

Keywords: Blood group incompatibility, Kidney transplantation, Immunosuppression, Antibodies

Figures and Tables

Fig. 1

Strategy for immunosuppressive therapy in ABO-incompatible kidney transplantation. It is important to implement B cell-mediated immunosuppression and T cell-mediated immunosuppression at different times; MMF, Mycophenolate mofetil; IVIG, Intravenous immunoglobulin.

emj-38-7-g001

Acknowledgements

This work was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (2010-0019866) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (2012R1A2A2A01013541).

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