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Kim, Shim, Kim, Kang, Ryu, Ahn, Jung, and Jung: The Trend of First-Line and Second-Line Eradication Rates for Helicobacter pylori Infection in a Single Institute in Seoul
Original Article

The Ewha Medical Journal 2014; 37(1): 26-29.

Published online: 25 March 2014

DOI: https://doi.org/10.12771/emj.2014.37.1.26

The Trend of First-Line and Second-Line Eradication Rates for Helicobacter pylori Infection in a Single Institute in Seoul

Mi Yeon Kim, Ki-Nam Shim, Hye-In Kim, Hyeon Ju Kang, Min Sun Ryu, So-Young Ahn, Hye Kyung Jung, Sung-Ae Jung

Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.

Corresponding author: Ki-Nam Shim. Department of Internal Medicine, Ewha Womans University School of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 158-710, Korea. Tel: 82-2-2650-2632, Fax: 82-2655-2076, shimkn@ewha.ac.kr

Received 30 August 2013       Accepted 11 October 2013

Copyright © 2014. Ewha Womans University School of Medicine

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives

To investigate the rate of first-line eradication and the rate of second-line eradication of Helicobacter pylori (H. pylori) from 2001 to 2010 in a single institute in Seoul.

Methods

Among the 2,717 patients who received H. pylori eradication treatment from 2001 to 2010 at Ewha Womans University Mokdong Hospital, the medical records of 1,466 patients who satisfied the condition of execution of upper gastrointestinal endoscopy, positive H. pylori eradication results at 6~8 weeks after eradication therapy were reviewed retrospectively. Then the first-line and second-line eradication rates and the eradication rates according to endoscopy findings were also compared.

Results

The first-line eradication rate was 77% H. pylori eradication rate for the last 5 years was continuously increasing and no sign of decline was observed even for the whole 10 years. The rates of eradication related to endoscopic findings showed statistical significance (P<0.001) of 79.8% and 70.1% each for peptic ulcer and non-ulcerative gastric diseases, respectively.

Conclusion

In this study, no decrease in tendency of first-line eradication rate could be found. In addition, the patients with the non-ulcerative gastric disease seemed to show significantly lower eradication rate. This finding suggests eradication treatment may be affected by the category of gastric diseases, and careful considerations should be taken assessing the effects and needs for the H. pylori eradication treatment.

Keywords: Helicobacter pylori, Eradication rate

Figures and Tables

Fig. 1
First-line eradication rate of Helicobacter pylori (per protocol analysis).
emj-37-26-g001
Fig. 2
Second-line eradication rate of Helicobacter pylori (per protocol analysis).
emj-37-26-g002
Fig. 3
Eradication rates according to endoscopic findings (peptic ulcer disease vs. non-peptic ulcer disease).
emj-37-26-g003
Table 1
Characteristics and endoscopic findings of patients
emj-37-26-i001

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