Abstract
Cancer prevention by vegetable diet has received considerable attention in recent years. In the past these attributes of vegetables were based more on beliefs than on scientific evidences. But over the past few decades many studies have been performed about that. Cancer preventive components of many vegetables have been studied in experimental carcinogenesis models. These studies have reported on these components influence carcinogenesis during initiation and promotion phases of cancer development. Also, epidemiological studies and clinical trials have reported cancer preventive effects of vegetables. However, there is no comprehensive summary of cancer preventive effects with the types of vegetables. In this review, we classified the vegetables and described the mechanism of action of active components of vegetables, experimental studies, and clinical trials. Results revealed a negative correlation between consumption of vegetables and cancer risk. But we can't still conclude the effects of vegetables yet, so further studies would be necessary for final conclusion.
References
1. Khachik F, Carvalho L, Bernstein PS, Muir GJ, Zhao DY, Katz NB. Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health. Exp Biol Med (Maywood). 2002. 227:845–851.
2. Sahin K, Sahin N, Kucuk O. Lycopene and chemotherapy toxicity. Nutr Cancer. 2010. 62:988–995.
3. Shahar S, Shafurah S, Hasan Shaari NS, Rajikan R, Rajab NF, Golkhalkhali B, et al. Roles of diet, lifetime physical activity and oxidative DNA damage in the occurrence of prostate cancer among men in Klang Valley, Malaysia. Asian Pac J Cancer Prev. 2011. 12:605–611.
4. Salem S, Salahi M, Mohseni M, Ahmadi H, Mehrsai A, Jahani Y, et al. Major dietary factors and prostate cancer risk: a prospective multicenter case-control study. Nutr Cancer. 2011. 63:21–27.
5. Antonious GF, Dennis SO, Unrine JM, Snyder JC. Ascorbic acid, β-carotene, sugars, phenols, and heavy metals in sweet potatoes grown in soil fertilized with municipal sewage sludge. J Environ Sci Health B. 2011. 46:112–121.
6. Holt PR. Dairy foods and prevention of colon cancer: human studies. J Am Coll Nutr. 1999. 18:5 Suppl. 379S–391S.
7. Wang LS, Stoner GD. Anthocyanins and their role in cancer prevention. Cancer Lett. 2008. 269:281–290.
8. MacDonald RS, Guo J, Copeland J, Browning JD, Sleper D, Rottinghaus GE, et al. Environmental influences on isoflavones and saponins in soybean and their role in colon cancer. J Nutr. 2005. 135:1239–1242.
9. Bennink MR. Dietary soy reduces colon carcinogenesis in human and rats: soy and colon cancer. Adv Exp Med Biol. 2001. 492:11–17.
10. Kang JH, Han IH, Sung MK, Yoo H, Kim YG, Kim JS, et al. Soybean saponin inhibits tumor cell metastasis by modulating expressions of MMP-2, MMP-9 and TIMP-2. Cancer Lett. 2008. 261:84–92.
11. Kang SY, Seera Seeram NP, Nair MG, Bourquin LD. Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. Cancer Lett. 2003. 194:13–19.
12. Harris GK, Gupta A, Nines RG, Kresty LA, Habib SG, Frankel WL, et al. Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2'-deoxyguanosine levels in the Fischer 344 rat. Nutr Cancer. 2001. 40:125–133.
13. Palozza P, Serini S, Di Nicuolo F, Calviello G. Modulation of apoptotic signaling by carotenoids in cancer cells. Arch Biochem Biophys. 2004. 430:104–109.
14. Cartea ME, Francisco M, Soengas P, Velasco P. Phenolic compounds in Brassica vegetables. Molecules. 2010. 16:251–280.
15. Murillo G, Mehta RG. Cruciferous vegetables and cancer prevention. Nutr Cancer. 2001. 41:17–28.
16. Kim JW. Complementary therapies and cancer treatment. J Korean Med Assoc. 2008. 51:427–434.
17. Weisberger AS, Pensky J. Tumor inhibition by a sulfhydryl-blocking agent related to an active principle of garlic (Allium sativum). Cancer Res. 1958. 18:1301–1308.
18. Herman-Antosiewicz A, Powolny AA, Singh SV. Molecular targets of cancer chemoprevention by garlic-derived organosulfides. Acta Pharmacol Sin. 2007. 28:1355–1364.
19. Brady JF, Ishizaki H, Fukuto JM, Lin MC, Fadel A, Gapac JM, et al. Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites. Chem Res Toxicol. 1991. 4:642–647.
20. Sparnins VL, Barany G, Wattenberg LW. Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse. Carcinogenesis. 1988. 9:131–134.
21. Rose DJ, DeMeo MT, Keshavarzian A, Hamaker BR. Influence of dietary fiber on inflammatory bowel disease and colon cancer: importance of fermentation pattern. Nutr Rev. 2007. 65:51–62.
22. Young GP, Hu Y, Le Leu RK, Nyskohus L. Dietary fiber and colorectal cancer: a model for environment-gene interactions. Mol Nutr Food Res. 2005. 49:571–584.
23. Howe GR, Benito E, Castelleto R, Cornee J, Esteve J, Gallagher RP, et al. Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies. J Natl Cancer Inst. 1992. 84:1887–1896.
24. Fuchs CS, Giovannucci EL, Colditz GA, Hunter DJ, Stampfer MJ, Rosner B, et al. Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med. 1999. 340:169–176.
25. Lin J, Zhang SM, Cook NR, Rexrode KM, Liu S, Manson JE, et al. Dietary intakes of fruit, vegetables, and fi ber, and risk of colorectal cancer in a prospective cohort of women (United States). Cancer Causes Control. 2005. 16:225–233.
26. Otani T, Iwasaki M, Ishihara J, Sasazuki S, Inoue M, Tsugane S. Dietary fiber intake and subsequent risk of colorectal cancer: the Japan Public Health Center-based prospective study. Int J Cancer. 2006. 119:1475–1480.
27. Shin A, Li H, Shu XO, Yang G, Gao YT, Zheng W. Dietary intake of calcium, fiber and other micronutrients in relation to colorectal cancer risk: Results from the Shanghai Women's Health Study. Int J Cancer. 2006. 119:2938–2942.