Abstract
Objective
The purpose of this study is to evaluate the relationship of insight with sociodemographic, clinical, and cognitive parameters in schizophrenic patients.
Methods
Seventy-seven patients with schizophrenia were recruited. All subjects completed the Korean version of the revised Insight Scale of Psychosis (KISP) and Multidimensional Scale of Perceived Social Support (MSPSS). Positive and Negative symptom scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), Neurocognitive function tests were also administered.
Results
Patients that are married or currently living together showed significantly higher levels of insight than those who are di-vorced, separated, or single. Insight showed positive correlations with CDSS and emotional discomfort factor of PANSS. Insight also had negative correlations with age of onset and family, friend subscales of MSPSS. Total scores of PANSS and neurocognitive functions showed no significant correlations with insight. More severe depressive symptoms, lower perceived social support from friends and family, and younger age of onset were predictor of higher insight.
REFERENCES
1). Rössler W, Salize HJ, van Os J, Riecher-Rössler A. Size of burden of schizophrenia and psychotic disorders. European Neuropsychopharmacology. 2005; 15:399–409.
2). Smith E, Weston CA, Lieberman A. Schizophrenia (maintenance treatment). Clinical Evidence. 2009; 04:1007.
4). Olfson M, Mechanic D, Hansell S, Boyer CA, Walkup J, Weiden PJ. Predicting medication noncompliance after hospital discharge among patients with schizophrenia; Psychiatric Services. 2014.
5). Donohoe G, Owens N, O'donnell C, Burke T, Moore L, Tobin A, et al. Predictors of compliance with neuroleptic medication among inpatients with schizophrenia: a discriminant function analysis. European Psychiatry. 2001; 16:293–298.
6). Lincoln TM, Lüllmann E, Rief W. Correlates and longterm con-sequences of poor insight in patients with schizophrenia. A system-atic review. Schizophrenia Bulletin. 2007; 33:1324–1342.
7). Buckley PF, Wirshing DA, Bhushan P, Pierre JM, Resnick SA, Wirshing WC. Lack of insight in schizophrenia. CNS Drugs. 2007; 21:129–141.
9). Cooke M, Peters E, Kuipers E, Kumari V. Disease, deficit or deni-al? Models of poor insight in psychosis. Acta Psychiatrica Scandinavica. 2005; 112:4–17.
11). Smith TE, Hull JW, Israel LM, Willson DF. Insight, symptoms, and neurocognition in schizophrenia and schizoaffective disorder. Schizophrenia Bulletin. 2000; 26:193.
12). J⊘rgensen P. Recovery and insight in schizophrenia. Acta Psychiatrica Scandinavica. 1995; 92:436–440.
14). Young DA, Davila R, Scher H. Unawareness of illness and neuropsychological performance in chronic schizophrenia. Schizophrenia Research. 1993; 10:117–124.
15). Raffard S, Bayard S, Gely-Nargeot M-C, Capdevielle D, Maggi M, Barbotte E, et al. Insight and executive functioning in schizophrenia: a multidimensional approach. Psychiatry research. 2009; 167:239–250.
16). Shad MU, Tamminga CA, Cullum M, Haas GL, Keshavan MS. Insight and frontal cortical function in schizophrenia: a review. Schizophrenia Research. 2006; 86:54–70.
17). Wiffen BD, Rabinowitz J, Lex A, David AS. Correlates, change and ‘state or trait'properties of insight in schizophrenia. Schizophrenia Research. 2010; 122:94–103.
18). Quee PJ, van der Meer L, Bruggeman R, de Haan L, Krabbendam L, Cahn W, et al. Insight in psychosis: relationship with neurocognition, social cognition and clinical symptoms depends on phase of illness. Schizophrenia Bulletin. 2011; 37:29–37.
19). White R, Bebbington P, Pearson J, Johnson S, Ellis D. The social con-text of insight in schizophrenia. Social psychiatry and psychiatric Epidemiology. 2000; 35:500–507.
20). First M. American psychiatric association diagnostic and statistical manual. APA Press, Washington DC. 1994.
21). Bell MD, Lysaker PH, Beam-Goulet JL, Milstein RM, Lindenmayer J-P. Five-component model of schizophrenia: assessing the facto-rial invariance of the positive and negative syndrome scale. Psychiatry Research. 1994; 52:295–303.
22). Markova I, Berrios G. The assessment of insight in clinical psychiatry: a new scale. Acta Psychiatrica Scandinavica. 1992; 86:159–164.
23). Marková IS, Roberts KH, Gallagher C, Boos H, McKenna PJ, Berrios GE. Assessment of insight in psychosis: a re-standardization of a new scale. Psychiatry Research. 2003; 119:81–88.
24). Kim J, Yim S, Yoon H. Assessing the reliability and validity of the Korean version of the Revised Insight Scale for Psychosis (KISP). Korean J Schizophr Res. 2004; 7:15–22.
25). Zimet GD, Dahlem NW, Zimet SG, Farley GK. The multidimensional scale of perceived social support. Journal of Personality Assessment. 1988; 52:30–41.
26). Shin J, Lee Y. The effects of social supports on psychosocial well-being of the unemployed. Korean J Soc Welf. 1999; 37:241–269.
27). Barrera A, McKenna PJ, Berrios GE. Formal thought disorder, neu-ropsychology and insight in schizophrenia. Psychopathology. 2009; 42:264–269.
28). Kim HJ, Kim SJ, Kong BG, Kang JW, Moon JJ, Jeon DW, et al. The Relationship of Cognitive Function and Psychosocial Factors with Occupational Rehabilitation in Patients with Schizophrenia. J Korean Soc Ther Psychiatry. 2014; 20:142–150.
29). MacPherson R, Jerrom B, Hughes A. Relationship between insight, educational background and cognition in schizophrenia. The British Journal of Psychiatry. 1996; 168:718–122.
30). Flashman LA, McAllister TW, Andreasen NC, Saykin AJ. Smaller brain size associated with unawareness of illness in patients with schizophrenia. American Journal of Psychiatry. 2000; 157:1167–1169.
31). Goldberg RW, Green-Paden LD, Lehman AF, Gold JM. Correlates of insight in serious mental illness. The Journal of Nervous and Mental Disease. 2001; 189:137–145.
32). Kim Y, Sakamoto K, Kamo T, Sakamura Y, Miyaoka H. Insight and clinical correlates in schizophrenia. Comprehensive Psychiatry. 1997; 38:117–123.
33). Navarro Marún F, Cardeño CA, Cano JF, Gómez JM, Jiménez K, Palacio CA, et al. Insight in Patients with Psychosis. Revista Colom-biana de Psiquiatría. 2006; 35:61–70.
34). Mintz AR, Dobson KS, Romney DM. Insight in schizophrenia: a metaanalysis. Schizophrenia Research. 2003; 61:75–88.
35). Drake R, Pickles A, Bentall R, Kinderman P, Haddock G, Tarrier N, et al. The evolution of insight, paranoia and depression during early schizophrenia. Psychological Medicine. 2004; 34:285–292.
36). Crumlish N, Whitty P, Kamali M, Clarke M, Browne S, McTigue O, et al. Early insight predicts depression and attempted suicide after 4 years in firstepisode schizophrenia and schizophreniform disorder. Acta Psychiatrica Scandinavica. 2005; 112:449–455.
37). Karow A, Pajonk F-G, Reimer J, Hirdes F, Osterwald C, Naber D, et al. The dilemma of insight into illness in schizophrenia: self-and expert-rated insight and quality of life. European Archives of Psychiatry and Clinical Neuroscience. 2008; 258:152–159.
38). Weiler MA, Fleisher MH, McArthur-Campbell D. Insight and symptom change in schizophrenia and other disorders. Schizophrenia Research. 2000; 45:29–36.
39). Peralta V, Cuesta MJ. Lack of insight: its status within schizophrenic psychopathology. Biological Psychiatry. 1994; 36:559–561.
40). Kim YL, Youn T, Kim MS. Cognitive Insight in Schizophrenic Patients. Kor J Clin Psyhcol. 2006; 25:1011–1027.
41). Lysaker P, Bell M. Insight and Cognitive Impairment in Schizophrenia Performance on Repeated Administrations of the Wisconsin Card Sorting Test. The Journal of Nervous and Mental Disease. 1994; 182:656–660.
Table 1.
Table 2.
Table 3.
Score of KISP |
||
---|---|---|
Mean± SD | p-value | |
Sex | ||
Male | 12.47±5.86 | 0.714 |
Female | 13.19±5.53 | |
Occupation | ||
Unemployed | 12.57±5.75 | 0.301 |
Employed | 14.10±5.31 | |
Marital status† | ||
Married/living together | 14.91±6.07 | 0.002∗ |
Single | 10.46±3.04 | |
Divorced/Separated | 09.00±4.31 |
Table 4.
R | p-value | |
---|---|---|
Age | -0.176 | 0.114∗ |
Educational level | -0.082 | 0.468∗ |
Onset age | -0.24 | 0.030∗ |
Duration of illness | 0.063 | 0.577∗ |
Number of hospitalization | 0.009 | 0.941∗ |
PANSS | ||
Negative factor | 0.139 | 0.236∗ |
Positive factor | 0.221 | 0.059∗ |
Cognitive factor | 0.071 | 0.549∗ |
Emotional discomfort factor | 0.311 | 0.007∗ |
Hostility factor | 0.039 | 0.741∗ |
CDSS | 0.532 | <0.001∗ |
MSPSS | ||
Family | -0.357 | 0.001∗ |
Friend | –0.369 | 0.001∗ |
Others | -0.161 | 0.149 |
Verbal IQ | -0.262 | 0.170∗ |
Performance IQ | -0.107 | 0.582 |
Total IQ | -0.108 | 0.551∗ |
Digit span | -0.047 | 0.680∗ |
Verbal fluency | -0.014 | 0.906∗ |
TMT A | 0.132 | 0.261∗ |
TMT B | 0.092 | 0.505∗ |
∗ : p<0.05, p-values were calculated using the Pearson's cor-relation analysis. KISP : Korean version of Insight Scale for Psychosis, PANSS : Positive and Negative symptoms scale, CDSS : Calgary Depression scale for Schizophrenia, MSPSS : Multidimensional Scale of Perceived social support, IQ : Intelligence