Journal List > Korean J Schizophr Res > v.16(2) > 1057797

Korean J Schizophr Res. 2013 Oct;16(2):98-106. Korean.
Published online October 31, 2013.
Copyright © 2013 Korean Society for Schizophrenia
Association between Mismatch Negativity and Functional Status in Patients with Schizophrenia
Min Ah Kim, MD,1 Sung Nyun Kim, MD,1,2 Min Hee Lee, RN,2 Suji Lee, MS,3 and Jun Soo Kwon, MD1,2,3
1Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
2Institute of Human Behavioral Sciences, Seoul National University-Medical Research Center, Seoul, Korea.
3Department of Brain and Cognitive Science-World Class University Program, Seoul National University College of Natural Science, Seoul, Korea.

Address for correspondence: Jun Soo Kwon, Department of Psychiatry, Seoul National University College of Medicine, 101 Daehak-no, Chongno-gu, Seoul 110-744, Korea. Tel: 02-2072-2450, Fax: 02-747-7405, Email:
Received September 04, 2013; Revised September 25, 2013; Accepted September 27, 2013.



It has been constantly reported that mismatch negativity (MMN) is impaired in patients with schizophrenia. However, the mechanism which relates impaired MMN and schizophrenia is not clear yet. The aim of this study is to investigate the association between MMN and clinical variables including functional status in patients with schizophrenia.


The present study assessed MMN using passive auditory oddball task in 26 patients with schizophrenia and 48 healthy controls. Repeated measures Analysis of Variance with age as a covariate was carried out for comparing peak amplitude and latency of MMN at 8 central line electrodes (FPz, Fz, FCz, Cz, CPz, Pz, POz, Oz) across groups. Pearson's correlation was performed to reveal the relationship between MMN and clinical variables including neurocognitive test results and the Global Assessment of Functioning score.


MMN amplitude was significantly reduced in patients with schizophrenia compared with healthy controls. Pearson's correlation showed that subsets of short form of Korean Wechsler Adult Intelligence Scale scores and GAF scores were associated with MMN amplitude in patients with schizophrenia.


These findings suggest that MMN amplitude is associated with current functional status including cognitive function in patients with schizophrenia.

Keywords: Event related potential; Mismatch negativity; Schizophrenia; Cognitive function; Functional status


Fig. 1
The grand averaged Mismatch negativity waveforms at Fz. A: Patients with schizophrenia. B: Healthy controls.
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Fig. 2
Mismatch negativity amplitude across group at Fz and Cz. Horizontal lines in the group indicate mean value and vertical lines in the group indicate 95% confidence interval.
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Fig. 3
Correlation between Mismatch negativity amplitudes and subsets of short form of Korean Wechsler Adult Intelligence Scale in patients with schizophrenia.
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Fig. 4
Correlation between Mismatch negativity amplitudes and Global Assessment of Functioning scores in patients with schizophrenia.
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Table 1
Demographic, neurocognitive and clinical characteristics of subjects
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Table 2
Means and standard deviations of peak MMN amplitudes and latencies at central electrode sites
Click for larger image

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