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Abstract
Objectives
There are emerging evidences suggest that the development of tardive dyskinesia (TD) is related to the oxidative stress, excitotoxicity, and immune activation. The purpose of this study is to investigate whether single-nucleotide polymorphisms (SNPs) of tumor necrosis factor (TNF)-α genes are associated with the susceptibility of TD and schizophrenia.
Methods
We investigated two hundred and eighty Korean schizophrenic patients. The schizophrenic participants consisted of patients with (n=105) and without (n=175) TD who were matched for antipsychotic drug exposure and other relevant variables. The TNF-α gene -308G/A SNPs were analyzed by polymerase chain reaction (PCR)-based methods.
Results
The frequencies of genotype (χ2=0.33, p=0.848) of the TNF-α gene -308 G/A SNP did not differ significantly between schizophrenic patients with and without TD. The difference of allele frequencies (χ2=0.28, p=0.594) of the TNF-α gene between the schizophrenic patients with and without TD were not significant.
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Table 1.
Comparison of the genotype and allele frequencies of TNF-α between schizophrenic patients with and without TD
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