Psychomotor Performance Relevant to Driving Ability in Patients with Schizophrenia Treated with Haloperidol and Aripiprazole

Ji Hyun Han; Se Jin Park; Jong Il Lee; An Kee Chang; Shi Hyun Kang; Minah Soh; Kyung Jin Lee; Eun Sang Koh; Sungwon Roh

doi:10.0000/kjsr.2012.15.2.99

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Han, Park, Lee, Chang, Kang, Soh, Lee, Koh, and Roh: Psychomotor Performance Relevant to Driving Ability in Patients with Schizophrenia Treated with Haloperidol and Aripiprazole

Original Article

Korean Journal of Schizophrenia Research

Korean Journal of Schizophrenia Research 2012; 15(2): 99-105.

Published online: 31 October 2012

DOI: https://doi.org/10.0000/kjsr.2012.15.2.99

Psychomotor Performance Relevant to Driving Ability in Patients with Schizophrenia Treated with Haloperidol and Aripiprazole

Ji Hyun Han, MD¹, Se Jin Park, MPH², Jong Il Lee, MD, PhD¹, An Kee Chang, MD¹, Shi Hyun Kang, MD, PhD¹, Minah Soh, MD¹, Kyung Jin Lee, MD¹, Eun Sang Koh, MD³, Sungwon Roh, MD, PhD^2,⁴

¹Department of Psychiatry, Seoul National Hospital, Seoul, Korea.

²Department of Mental Health Research, Seoul National Hospital, Seoul, Korea.

³Ansan Yoon Neuropsychiatric Clinic, Ansan, Korea.

⁴Center for Addiction Medicine, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Address for correspondence: Sungwon Roh, Department of Mental Health Research, Seoul National Hospital, 51 Neungdong-ro, Gwangjin-gu, Seoul 143-711, Korea. Tel: 02-2204-0292, Fax: 02-2204-0280, swroh@korea.kr

Received 22 August 2012 Revised 20 September 2012 Accepted 24 September 2012

Abstract

Objectives

This study aimed to compare psychomotor performance related with automobile driving in patients with schizophrenia under the treatment of a typical antipsychotic agent, haloperidol, or an atypical antipsychotic agent, aripiprazole.

Methods

We evaluated driving ability of schizophrenia patients by using the cognitive perceptual assessment for driving (CPAD). Twelve patients receiving haloperidol monotherapy and 18 taking aripiprazole monotherapy participated in this study and the results of CPAD were compared with each other.

Results

Of 30 participants, 15 (50%) of the patients passed the CPAD to be regarded as competent to drive, 3 (10%) of the patients failed the CPAD considered to be severely impaired. Controlling for sex, age, education, duration of illness, there were no significant differences in the CPAD results between two treatment groups. We observed a trend that patients who received aripiprazole showed a higher total score of the CPAD than haloperidol-treated patients (55.2±4.9 vs. 45.7±8.4, p=0.080).

Conclusion

There were no significant differences in the psychomotor performance relevant to driving ability between haloperidol and aripiprazole groups. But our results suggest that aripiprazole might have the neurocognitive advantage over haloperidol. Future study with a large sample size and diverse antipsychotics is warranted.

Keywords: Schizophrenia, Haloperidol, Aripiprazole, Driving, Psychomotor performance

Figures and Tables

Fig. 1

Global driving ability of schizophrenia patients.

Table 1

Demographic and clinical characteristics of the subjects

Values are shown as Mean±SD or number (%). PANSS : positive and negative syndrome scale, ESRS : extrapyramidal symptom rating scale

Table 2

CPAD performance for all variables of schizophrenia patients

Values are shown as Mean±SD. * : Adjusted for sex, age, education, and duration of illness. CPAD : cognitive perceptual assessment for driving, NCR : numbers of correct response, RT : reaction time

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