Multidimensional Comparison of Personality Characteristics in Genetic High Risk for Schizophrenia, First Episode Psychosis and Healthy Controls

Jae Wook Han; Sung Nyun Kim; Jin Woo Park; Je-Yeon Yun; Na young Shin; Ji-Won Hur; Seung Won Kim; Jun Soo Kwon

doi:10.0000/kjsr.2012.15.2.73

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Han, Kim, Park, Yun, Shin, Hur, Kim, and Kwon: Multidimensional Comparison of Personality Characteristics in Genetic High Risk for Schizophrenia, First Episode Psychosis and Healthy Controls

Original Article

Korean Journal of Schizophrenia Research

Korean Journal of Schizophrenia Research 2012; 15(2): 73-80.

Published online: 31 October 2012

DOI: https://doi.org/10.0000/kjsr.2012.15.2.73

Multidimensional Comparison of Personality Characteristics in Genetic High Risk for Schizophrenia, First Episode Psychosis and Healthy Controls

Jae Wook Han, MD¹, Sung Nyun Kim, MD¹, Jin Woo Park, MD¹, Je-Yeon Yun, MD¹, Na young Shin, MA³, Ji-Won Hur, MA², Seung Won Kim³, Jun Soo Kwon, MD, PhD^1,^2,³

¹Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.

²Department of Brain and Cognitive Sciences-World Class University Program, College of Natural Sciences, Seoul National University, Seoul, Korea.

³Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Korea.

Address for correspondence: Jun Soo Kwon, Department of Psychiatry, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea. Tel: 02-2072-2972, Fax: 02-747-9063, kwonjs@snu.ac.kr

Received 30 August 2012 Revised 18 September 2012 Accepted 26 September 2012

Abstract

Objectives

Previous studies have suggested that some personality characteristics are associated with the onset, prognosis and social function in schizophrenia patients. However few is known about the personality and affective characteristic of genetic high risk group (GHR) for schizophrenia. This study aimed to investigate the personality and the affective characteristic of GHR group for schizophrenia.

Methods

Participants were 54 healthy controls (HC), 26 subjects with GHR for schizophrenia and 28 subjects with first episode psychosis (FEP). We performed three self-report questionnaires; NEO-Personality Inventory-Revised, State and Anger Expression Inventory and Positive Affect and Negative Affect Schedule.

Results

The GHR group showed higher score in agreeableness item than the HC (p=0.028). In extraversion item, the FEP group showed significantly lower scores than the HC (p=0.001). The GHR group showed lower scores in neuroticism item compared with FEP group in trend level. The FEP group showed higher trait-anger, lower positive affect and higher negative affect compared with the others.

Conclusion

The GHR group seem to share certain vulnerable personality and affective characteristics for schizophrenia with the FEP group. On the other hands, the GHR group appeared to be more agreeable than the other groups, which might act as the compensation for other impaired functions.

Keywords: NEO-Personality Inventory-Revised (NEO-PI-R), Five Factor Model (FFM), State and Anger Expression Inventory (STAXI), Positive Affect and Negative Affect Schedule (PANAS), Genetic High Risk (GHR), Schizophrenia

Figures and Tables

Fig. 1

Profiles of the personality dimensions of HC, GHR and FEP group. Error bars with 95% Confidence Interval. Agreeableness, conscientiousness, extraversion, neuroticism, and openness to experience were measured by the NEO-PI-R. ^*: p<0.05. GHR : genetic high risk, FEP : first episode psychosis, HC : healthy controls, NEO-PI-R NEO personality. Inventory-revised.

Fig. 2

Profiles of the affective dimensions of HC, GHR and FEP group. Error bars with 95% Confidence Interval. State- and trait-anger were measured by STAXI. Positive and negative affect were measured by the PANAS. ^*: p<0.05. GHR : genetic high risk, FEP : first episode psychosis, HC : healthy controls, STAXI : state trait anger expression inventory, PANAS : positive affect and negative affect schedule.

Table 1

Demographic and clinical characteristics in HC, GHR and FEP

Data are presented as means (SDs). ^*: p<0.05, ^†: HC vs. FEP. HC : healthy controls, GHR : genetic high risk, FEP : first episode psychosis

Table 2

Comparison of personality dimensions of the NEO-PI-R, PANAS and STAXI in HC, GHR and FEP group

Data are presented as Mean (SDs). ^*: p<0.05, ^†: HC vs. FEP, ^‡: HC vs. GHR, ^§: GHR vs. FEP. HC : healthy controls, GHR : genetic high risk, FEP : first episode psychosis, NEO-PI-R : NEO personality inventory-revised, STAXI : state trait anger expression inventory, PANAS : positive affect and negative affect schedule

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