Two Clinical Cases of Anti-Dib with Di(a+b-) Phenotypes: Practical Need for Rare Blood Donor Registry Program in Korea

Min Young Lee; Tae Sung Park; Seung Hwan Oh; Sinyoung Kim; Hyun-Ok Kim

doi:10.3343/lmo.2017.7.2.79

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Lee, Park, Oh, Kim, and Kim: Two Clinical Cases of Anti-Dib with Di(a+b-) Phenotypes: Practical Need for Rare Blood Donor Registry Program in Korea

Original Article

Lab Med Online 2017;7(2):79-82.

Published online: 17 April 2017

DOI: https://doi.org/10.3343/lmo.2017.7.2.79

Two Clinical Cases of Anti-Di^b with Di(a+b-) Phenotypes: Practical Need for Rare Blood Donor Registry Program in Korea

Min Young Lee, M.D.^1,², Tae Sung Park, M.D.^2,^∗,, Seung Hwan Oh, M.D.³, Sinyoung Kim, M.D.^4,^∗,, Hyun-Ok Kim, M.D.⁴

¹Department of Laboratory Medicine, Graduate School, Kyung Hee University, Seoul, Korea

²Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea

³Department of Laboratory Medicine, Inje University College of Medicine, Busan, Korea

⁴Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea

^∗ These authors contributed equally to this article as the co-corresponding authors.

Corresponding author: Tae Sung Park Department of Laboratory Medicine, School of Medicine, Kyung Hee University, 23 Kyung Hee dae-ro, Dongdaemun-gu, Seoul 02447, Korea Tel: +82-2-958-8673, Fax: +82-2-958-8609, E-mail: 153jesus@hanmail.net

Co-corresponding author: Sinyoung Kim Department of Laboratory Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea Tel: +82-2-2228-2452, Fax: +82-2- 313-0956, E-mail: SYKIM@yuhs.ac

Received 21 June 201611 October 2016 Accepted 19 October 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Here, we report two cases of identified anti-Di^b antibodies with rare Di(a+b-) blood types from two different hospitals in Korea. Di^b mismatched transfusion could cause a hemolytic transfusion reaction. However, it is extremely difficult to find compatible blood for patients with such a rare blood type. In this regard, we concluded that national level rare donor registry program, wherein rare blood types are indexed, needs to be established. Moreover, laboratory medicine specialists at each hospital should encourage donor registration and family testing through education for helping patients with rare blood types. These efforts will help establish a system that guarantees safe blood transfusion for patients.

Keywords: Rare blood donor registry program, Anti-Di^b, Transfusion

REFERENCES

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Fig. 1.

Hemoglobin value of the patient in Case 1.

Fig. 2.

Sequence analysis of SLC4A1. Arrow indicates homozygous substitution of proline (CCG) with leucine (CTG) at position 854 of exon 19.

Fig. 3.

Proposed protocol after identifying rare blood type in a patient.

Table 1.

Reported cases of adult patients having anti-Di^b in Korea

Case	Age/Sex	Blood group	Diego phenotype	Unexpected antibody identification	Diagnosis
1 [14]	57/F	N/A	Di(a+b−)	anti-Di^b	Liver cancer
2 [present case]	78/F	O+	Di(a+b−)	anti-Di^b	Compartment syndrome
3 [present case]	73/F	A+	Di(a+b−)	anti-Di^b, anti-C	Humerus fracture

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