Journal List > Lab Med Online > v.6(2) > 1057333

Lee, Park, Seo, Ahn, Seo, Jeong, Kim, Lee, Lee, and Kim: Massive Transfusion Protocols for Pediatric Patients

Abstract

The number of massive transfusions for pediatric patients has risen owing to the increasing number of complex surgeries and trauma centers. However, as there are only a few studies on pediatric massive transfusion, adult massive transfusion protocols are used for pediatric patients in many hospitals and institutions. Although massive transfusion protocols would improve the outcomes and reduce the received blood products during transfusion, pediatric patients differ from adults in the tolerability to transfusion, incidence of coagulopathy, and mechanisms of injuries. Therefore clinical physicians have requested for a pediatric massive transfusion protocol. Herein, we reviewed pediatric massive transfusion protocols that have been used in various clinical settings. To date, only a few single-center studies with a small number of pediatric patients have been performed. Even though these studies did not show improvement in outcomes such as mortality and side effects, they reported a short preparation time for fresh frozen plasma products and a low coagulopathy rate in pediatric massive transfusion groups. Therefore, large, prospective, multicenter studies are needed to identify the empiric ratio of blood products for improving outcomes of pediatric patients who need massive transfusion.

Figures and Tables

Fig. 1

Size-adjusted packages for the pediatric trauma massive transfusion protocol, as described by Hendrickson et al. *unit; apheresis.

lmo-6-60-g001

Notes

This article is available from http://www.labmedonline.org

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