A Case of Septic Shock Following Catheter-related Infection Caused by Lactococcus lactis subsp. lactis in an Adult

Tae Won Bae; Jaehyeon Lee; Hye Soo Lee; Yong Gon Cho

doi:10.3343/lmo.2016.6.3.187

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Bae, Lee, Lee, and Cho: A Case of Septic Shock Following Catheter-related Infection Caused by Lactococcus lactis subsp. lactis in an Adult

Original Article

Lab Med Online 2016;6(3):187-190.

Published online: 17 July 2016

DOI: https://doi.org/10.3343/lmo.2016.6.3.187

A Case of Septic Shock Following Catheter-related Infection Caused by Lactococcus lactis subsp. lactis in an Adult

Tae Won Bae, M.D.¹, Jaehyeon Lee, M.D.^1,², Hye Soo Lee, M.D.^1,^2,³, Yong Gon Cho, M.D.^1,^2,^3,

¹Department of Laboratory Medicine, Chonbuk National University Medical School, Jeonju, Korea

²Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea

³Chonbuk National University Hospital Branch of National Culture Collection for Pathogens, Jeonju, Korea

Corresponding author: Yong Gon Cho Department of Laboratory Medicine, Chonbuk National University Medical School, 20 Geonjiro, Deokjin-gu, Jeonju 54907, Korea Tel: +82-63-250-2388, Fax: +82-63-250-1200, E-mail: choyg@jbnu.ac.kr

Received 20 July 201517 August 2015 Accepted 19 August 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Lactococcus lactis is a gram-positive cocci used extensively in the dairy industry, but considered an unusual pathogen in humans. Among its five subspecies, L. lactis subsp. lactis in particular has rarely been reported as a pathogen. We report a case of septic shock caused by L. lactis subsp. lactis in an adult patient. A 64-yr-old male patient was admitted to outpatient clinics, with chief complaints of fever and chills for one week after convalescent hospital admission. He had severe ileus requiring surgery. He had a peripherally inserted central catheter from convalescent hospital, which was immediately removed. From two sets of blood and catheter tip cultures, we identified L. lactis subsp. lactis using the Vitek 2 system (bioMerieux Inc., USA), and confirmed this result by 16S rRNA sequencing. The patient was empirically treated with ciprofloxacin, and he recovered and was discharged.

Keywords: Lactococcus lactis subsp. lactis, Catheter-related infections, Septic shock

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Table 1.

Cases of L. lactis subsp. lactis-associated infections reported to date

Year	Age	Sex	Site of infection	Exposure to unpasteur-ized milk products	Treatment	Outcome	Immune status
2006 [15]	55	M	Endocarditis	Not reported	Amoxicillin-clavulanic acid with surgery	At 3 months of followup, symptom free	Normal
2010 [7]	1	F	Catheter-related	None	Vancomycin	Improved after 2 days; clear-	Preterm with small gestational
			bacteremia			ance of bacteremia without removal of catheter	age; short bowel syndrome
2014 [8]	1	M	Catheter-related bacteremia	None	Vancomycin	Continued to improve without removal of the central venous catheter	t Down's syndrome and Hirschprung's disease

Abbreviations: M, male; F, Female

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