Epidemiology and Resistance Patterns of Bacterial Pathogens in Urinary Tract Infections in the Northern Gyeonggi-do Area during 2007-2011

Eunyoung Oh; Hyukmin Lee; Hwan Sub Lim; Younhee Park

doi:10.3343/lmo.2013.3.1.34

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Oh, Lee, Lim, and Park: Epidemiology and Resistance Patterns of Bacterial Pathogens in Urinary Tract Infections in the Northern Gyeonggi-do Area during 2007-2011

Original Article

Clinical Microbiology

Laboratory Medicine Online

Laboratory Medicine Online 2013; 3(1): 34-39.

Published online: 1 January 2013

DOI: https://doi.org/10.3343/lmo.2013.3.1.34

Epidemiology and Resistance Patterns of Bacterial Pathogens in Urinary Tract Infections in the Northern Gyeonggi-do Area during 2007-2011

Eunyoung Oh, M.D., Hyukmin Lee, M.D., Hwan Sub Lim, M.D., Younhee Park, M.D.

Department of Laboratory Medicine, Kwandong University College of Medicine, Goyang, Korea.

Corresponding author: Hyukmin Lee, M.D. Department of Laboratory Medicine, Kwandong University, Myongji Hospital, 55 Hwasun-ro 14beon-gil, Deokyang-gu, Goyang 412-826, Korea. Tel: +82-31-810-7083, Fax: +82-31-962-1352, hmlee.labmed@gmail.com

Received 4 September 2012 Revised 27 September 2012 Accepted 28 September 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

Bacteria that cause urinary tract infections (UTIs) are found with different frequencies in different regions; moreover, antibiotic susceptibility can also vary by region. We retrospectively studied and compared the species and antimicrobial susceptibility of bacterial pathogens isolated from patients with UTIs in the northern Gyeonggi-do area.

Methods

We analyzed urine specimens collected from patients who visited the Myongji Hospital between 2007 and 2011. The urine specimens were cultured, and bacteria were identified by biochemical examination with an API kit (bioMerieux Inc., USA). Antimicrobial susceptibility was determined by the disc diffusion method and the Vitek II system (bioMerieux Inc., USA).

Results

A total of 11,818 (31.4%) urine specimens were culture positive. The most common species identified were Escherichia coli (37.1%), Klebsiella pneumoniae (7.4%), Enterococcus faecium (6.1%), and Candida spp. (5.5%). The proportion of isolates producing extended-spectrum β-lactamases significantly increased during the study period.

Conclusions

E. coli, K. pneumoniae, and E. faecium were the 3 most common organisms identified. Of note, however, was the increasing frequency of Pseudomonas spp. and Proteus spp. isolated during the more recent years. Further studies are required from other centers in the northern Gyeonggi-do area.

Keywords: Urinary tract infection, Urine culture, Antibiotic susceptibility testing

Figures and Tables

Fig. 1

Antimicrobial resistance trend of major antibiotic-resistant bacteria isolated from the northern Gyeonggi area hospital.

Abbreviations: MRCoNS, methicillin-resistant coagulase-negative staphylococci; VAN-R-EFM, vancomycin-resistant E. faecium; ESBL-ECO, extended-spectrum β-lactamase producing E. coli; ESBL-KPN, extended-spectrum β-lactamase producing K. pneumoniae; MRSA, methicillin-resistant Staphylococcus aureus.

Table 1

Distribution of causative organisms of urinary tract infections from 2007 to 2011

Abbreviation: CoNS, coagulase-negative staphylococci.

Table 2

Distribution of causative organisms of urinary tract infections according to wards and visit

Abbreviations: OPD, outpatient department; ER, emergency room; ICU, intensive care unit; CoNS, coagulase-negative staphylococci.

Table 3

Distribution of causative organisms of urinary tract infections according to the specimen sampling technique

Abbreviation: CoNS, coagulase-negative staphylococci.

Table 4

Distribution of antimicrobial resistance of major uropathogens

Abbreviations: CoNS, coagulase-negative staphylococci; ESBL, extended-spectrum β-lactamase; ICR, inducible clindamycin resistance.

Notes

This article is available from http://www.labmedonline.org

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