A Case of Acute Myeloid Leukemia Transformed from JAK2 V617F-Positive Chronic Neutrophilic Leukemia

Jae-Hee Lee; Jung-Sook Ha; Nam-Hee Ryoo; Dong-Seok Jeon; Jae-Ryong Kim

doi:10.3343/lmo.2012.2.2.101

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Lee, Ha, Ryoo, Jeon, and Kim: A Case of Acute Myeloid Leukemia Transformed from JAK2 V617F-Positive Chronic Neutrophilic Leukemia

Case Report

Diagnostic Hematology

Laboratory Medicine Online

Laboratory Medicine Online 2012; 2(2): 101-104.

Published online: 30 March 2012

DOI: https://doi.org/10.3343/lmo.2012.2.2.101

A Case of Acute Myeloid Leukemia Transformed from JAK2 V617F-Positive Chronic Neutrophilic Leukemia

Jae-Hee Lee, M.D., Jung-Sook Ha, M.D., Nam-Hee Ryoo, M.D., Dong-Seok Jeon, M.D., Jae-Ryong Kim, M.D.

Department of Laboratory Medicine, Keimyung University School of Medicine, Daegu, Korea.

Corresponding author: Jung-Sook Ha, M.D. Department of Laboratory Medicine, Keimyung University School of Medicine, 194 Dongsan-dong, Jung-gu, Daegu 700-712, Korea. Tel: +82-53-250-7266, Fax: +82-53-250-7275, ksksmom@dsmc.or.kr

Received 11 August 2011 Revised 18 November 2011 Accepted 15 December 2011

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm (MPN) characterized by persistent peripheral blood neutorphilia, bone marrow hypercellularity of neutrophilic granulocyte proliferation and hepatosplenomegaly. Acquired somatic mutation, JAK2 V617F, is the only molecular marker known to have association with classic BCR-ABL1 negative MPNs. However, JAK2 V617F has been detected occasionally in other MPNs such as CNL or other disease entities. We experienced a case of CNL with JAK2 V617F mutation. The patient was diagnosed according to the 2008 WHO classification criteria, and developed AML 9 months after the diagnosis of CNL. The JAK2 V617F was detected in the bone marrow throughout the clinical course. More cases are needed to establish the role of JAK2 V617F in the pathogenesis, prognosis and disease course of CNL.

Keywords: AML, Chronic neutrophilic leukemia, JAK2 V617F, Myeloproliferative neoplasm

Figures and Tables

Fig. 1

The peripheral blood smear shows marked neutrophilic leukocytosis (Wright stain, ×400).

Fig. 2

The bone marrow aspirate at diagnosis shows marked myeloid hyperplasia, particularly mature neutrophils (Wright stain, ×1,000).

Fig. 3

The bone marrow aspirate 9 months after diagnosis shows proliferation of myeloblasts. The arrow indicates a blast with auer rod (Wright stain, ×1,000).

Fig. 4

The chromatogram of direct sequencing for JAK2 exon 14. The JAK2 V617F mutation is detected in serial three bone marrow samples. The arrows indicate the substitution of Guanine to Thymine base result in the JAK2 V617F mutation.

References

1. Swerdlow SH, Campo E, editors. World Health Organization classification of tumours of haematopoietic and lymphoid tissues. 2008. 4th ed. Lyon: IARC;38–39.

2. Jones AV, Kreil S, Zoi K, Waghorn K, Curtis C, Zhang L, et al. Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood. 2005. 106:2162–2168.

3. Mc Lornan DP, Percy MJ, Jones AV, Cross NC, MC Mullin MF. Chronic neutrophilic leukemia with an associated V617F JAK2 tyrosine kinase mutation. Haematologica. 2005. 90:1696–1697.

4. Steensma DP, Dewald GW, Lasho TL, Powell HL, Mc Clure RF, Levine RL, et al. The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes. Blood. 2005. 106:1207–1209.

5. Lea NC, Lim Z, Westwood NB, Arno MJ, Gäken J, Mohamedali A, et al. Presence of JAK2 V617F tyrosine kinase mutation as a myeloid-lineage-specific mutation in chronic neutrophilic leukaemia. Leukemia. 2006. 20:1324–1326.

6. Kako S, Kanda Y, Sato T, Goyama S, Noda N, Shoda E, et al. Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation. Am J Hematol. 2007. 82:386–390.

7. Reilly JT. Chronic neutrophilic leukaemia: a distinct clinical entity? Br J Haematol. 2002. 116:10–18.

8. Elliott MA. Chronic neutrophilic leukemia: a contemporary review. Curr Hematol Rep. 2004. 3:210–217.

9. Lim TH, Jin TS, Kuon IS, Sun DJ, Lee EH, Cho HC. A case of chronic neutrophilic leukemia. The first report in Korea. Korean J Hematol. 1987. 22:337–343.

10. Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med. 2005. 352:1779–1790.

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