Journal List > Kosin Med J > v.31(2) > 1057082

Kim, Kim, Lee, Kim, and Oh: The Role of Vitamin D in Menopausal Medicine

Abstract

Menopause is the time at which menstruation stops in women. After menopause, women are more susceptible to some diseases, especially osteoporosis and cardiovascular disease. Vitamin D has a protective effect against osteoporosis by facilitating the absorption of calcium and affecting parathyroid hormone. Vitamin D also affects cardiovascular function by lowering the blood pressure, which affects the renin–angiotensin system and alters the low-density lipoprotein receptor activity. This paper discusses supplemental vitamin D in postmenopausal women with osteoporosis and cardiovascular disease.

References

1. Lips P, van Schoor NM. The effect of vitamin D on bone and osteoporosis. Best pract Res Clin Endocrinol Metab. 2011; 25:585–91.
crossref
2. Dong J, Lau CW, Wong S, Huang Y. Cardiovascular benefits of vitamin D. Sheng Li Xue Bao. 2014; 66:30–6.
3. Kim JS, Choi YJ, Lee KW, Song IJ, Kim CA, Son BH, et al. The study in vitamin D concentration in the blood for infants with high level of alkaline phosphatase. Kosin Med J. 2012; 27:17–24.
crossref
4. Kim TH, Lee HH, Kim JM. Letters to the Editor. Menopause. 2015; 22:797.
crossref
5. Kim TH, Lee HH, Kim JM. Comments on vitamin D. Maturitas. 2015; 81:329.
crossref
6. Han MJ, Lee JH. Factors influencing self-identity and menopausal symptoms on level of depression in middle aged women. Korean J Women Health Nurs. 2013; 19:275–84.
crossref
7. Kwak EK, Park HS, Kang NM. Menopause knowledge, attitude, symptom and management among midlife employed women. J Menopausal Med. 2014; 20:118–25.
crossref
8. LeBlanc ES, Hedlin H, Qin F, Desai M, Wactawski-Wende J, Perrin N, et al. Calcium and vitamin D supplementation do not influence menopause-related symptoms: Results of the Women's Health Initiative Trial. Maturitas. 2015; 81:377–83.
crossref
9. Kim HY, Kong EH. The Association between serum GGT level and bone mineral density in postmenopausal women. Kosin Med J. 2013; 28:35–41.
crossref
10. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001; 22:477–501.
crossref
11. Limpaphayom KK, Kim HY. Diagnosis and treatment of osteoporosis. Kosin Med J. 2011; 26:121–6.
12. Choi SH, Lee DJ, Kim KM, Kim BT. Association between seasonal changes in vitamin D and bone mineral density. J Korean Soc Menopause. 2011; 17:88–93.
13. Cândido FG, Bressan J. Vitamin D: link between osteoporosis, obesity, and diabetes? Int J Mol Sci. 2014; 15:6569–91.
crossref
14. Kuchuk NO, Pluijm SM, van Schoor NM, Looman CW, Smit JH, Lips P. Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons. J Clin Endocrinol Metab. 2009; 94:1244–50.
crossref
15. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006; 354:669–83.
16. Robbins JA, Aragaki A, Crandall CJ, Manson JE, Carbone L, Jackson R, et al. Women's Health Initiative clinical trials: interaction of calcium and vitamin D with hormone therapy. Menopause. 2014; 21:116–23.
17. Chlebowski RT, Pettinger M, Johnson KC, Wallace R, Womack C, Mossavar-Rahmani Y, et al. Calcium plus vitamin D supplementation and joint symptoms in postmenopausal women in the women's health initiative randomized trial. J Acad Nutr Diet. 2013; 113:1302–10.
crossref
18. Wolpin BM, Ng K, Bao Y, Kraft P, Stampfer MJ, Michaud DS, et al. Plasma 25-hydroxyvitamin D and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2012; 21:82–91.
crossref
19. Norman PE, Powell JT. Vitamin D and cardiovascular disease. Circ Res. 2014; 114:379–93.
crossref
20. Li YC, Qiao G, Uskokovic M, Xiang W, Zheng W, Kong J. Vitamin D: a negative endocrine regulator of the renin–angiotensin system and blood pressure. J Steroid Biochem Mol Biol. 2004; 89–90:387–92.
crossref
21. Li YC. Vitamin D regulation of the renin–angio-tensin system. J Cell Biochem. 2003; 88:327–31.
crossref
22. Pérez-López FR. Vitamin D metabolism and cardiovascular risk factors in postmenopausal women. Maturitas. 2009; 62:248–62.
crossref
23. Kim TH, Park J, Lee HH, Lee WS, Chung SH, Park Y, et al Expression of vitamin D receptor by pulse consumption in the uterus of menopausal mouse model. J Korean Soc Menopause. 2013; 19:1–8.
24. Kim TH, Lee HH, Park J. Immunohistochemical detection of the 1,25-dihydroxy vitamin D receptor in the human vagina. Iran J Reprod Med. 2014; 12:805–10.
25. Cauley JA, Chlebowski RT, Wactawski-Wende J, Robbins JA, Rodabough RJ, Chen Z, et al. Calcium plus vitamin D supplementation and health outcomes five years after active intervention ended: the Women's Health Initiative. J Womens Health (Larchmt). 2013; 22:915–29.
crossref
26. Rejnmark L, Avenell A, Masud T, Anderson F, Meyer HE, Sanders KM, et al. Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials. J Clin Endocrinol Metab. 2012; 97:2670–81.
crossref

TOOLS
Similar articles