Journal List > Kosin Med J > v.30(2) > 1057049

Park, Kim, Choi, Lim, Yi, Lee, and Kim: A Case of Disseminated Extranodal Interdigitating Dendritic Cell Sarcoma Arising from Parotid Gland

Abstract

Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare tumor derived from professional antigen presenting cell and primarily found in lymph nodes, with rarer case report about extranodal presentation of IDCS. A 71-yr-old man was admitted with progressively enlarging and painless mass in the right parotid area for 2 months. Computed tomography of the neck and chest revealed enhancing mass in right parotid gland, multiple lymphadenopathies around neck and mediastinum, and an osteolytic metastasis at thoracic spine. Morphological and immunohistochemical analysis of an excisional biopsy specimen from parotid mass were consistent with a diagnosis of IDCS. Palliative chemotherapy with 6 cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) regimen and 2 cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) regimen plus radiotherapy on parotid mass failed in tumor reduction. We describe a rare case of disseminated extranodal IDCS arising from parotid gland.

References

1. Kairouz S, Hashash J, Kabbara W, McHayleh W, Tabbara IA. Dendritic cell neoplasms: an overview. Am J Hematol. 2007; 82:924–8.
crossref
2. Saygin C, Uzunaslan D, Ozguroglu M, Senocak M, Tuzuner N. Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. Crit Rev.
3. Han HS, Lee OJ, Lim SN, An JY, Lee KM, Choe KH, al. Extranodal interdigitating dendritic cell sarcoma presenting in the pleura: a case report. J Korean Med Sci. 2011; 26:304–7.
4. Kim SY, Kang JH, Chun SH, Chang MH, Kim YS, Lee SN, et al. Interdigitating dendritic cell sarcoma of the tonsil. Asia Pac J Clin Oncol. 2010; 6:144–8.
crossref
5. Lee SY, Lee SR, Chang WJ, Kim HS, Kim BS, Kim IS. Successful treatment of disseminated interdigitating dendritic cell sarcoma with adriamycin, bleomycin, vinblastine, and dacarbazine chemotherapy. Korean J Hematol. 2012; 47:150–3.
crossref
6. Lee EJ, Hyun DW, Cho HY, Lee JG. A Rare Case of Interdigitating Dendritic Cell Sarcoma in the Nasal Cavity. Case Rep Otolaryngol. 2013; 2013:913157.
crossref
7. Han SW, Kim ZS, Kim HM, Lee J, Kang GH, Cho HD, et al. Interdigitating dendritic cell sarcoma occurred alone in axilla. J Korean Surg Soc. 2012; 82:330–4.
8. Efune G, Sumer BD, Sarode VR, Wang HY, Myers LL. Interdigitating dendritic cell sarcoma of the parotid gland: case report and literature review. Am J Otolaryngol. 2009; 30:264–8.
crossref
9. Schraven SP, Plontke SK, Syha R, Fend F, Wolburg H, Adam P. Dendritic cell tumor in a salivary gland lymph node: a rare differential diagnosis of salivary gland neoplasms. Diagn Pathol. 2011; 6:94.
crossref
10. De Pas T, Spitaleri G, Pruneri G, Curigliano G, Noberasco C, Luini A, et al. Dendritic cell sarcoma: an analytic overview of the literature and presentation of original five cases. Crit Rev Oncol Hematol. 2008; 65:1–7.
crossref
11. Pileri SA, Grogan TM, Harris NL, Banks P, Campo E, Chan JK, et al. Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology. 2002; 41:1–29.
crossref
12. Ralfkiaer E, Delsol G, O'Connor NT, Brandtzaeg P, Brousset P, Vejlsgaard GL, et al. Malignant lymphomas of true histiocytic origin. A clinical, histological, immunophenotypic and genotypic study. J Pathol. 1990; 160:9–17.
crossref
13. Barwell N, Howatson R, Jackson R, Johnson A, Jarrett RF, Cook G. Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection. J Clin Pathol. 2004; 57:87–9.
crossref

Fig. 1.
 
kmj-30-163f1.tif
Fig. 2.
 
kmj-30-163f2.tif
Fig. 3.
 
kmj-30-163f3.tif
Table 1.
Demographic and clinical features of reported and Korean cases.
  Reported cases (N = 100) Korean cases (N = 5)
Age    
Median (range), yr 56.5 (1.8 – 88) 57 (32 – 73)
Sex    
Male:female (ratio) 58:42 (1.38:1) 2:3 (1:1.5)
Presentationa    
Localized 59% (45/76) 20% (1/5)
Locally advanced 5.3% (4/76) 40% (2/5)
Metastatic 35.6% (27/76) 40% (2/5)
Involved sites (number of cases)    
Lymph nodes    
Cervical 41 2
Axillary 22 2
Mediastinal 9
Intraabdominal 18
Exrtanodal sites    
Tonsil 3 1
Nasopharynx 3 2
Soft tissue 1 1
Bone 5 1
Pleura 3 1
Treatment (number of cases)a    
Surgery alone 21/76
Surgery plus adjuvant therapy 18/76 1/5
Radiation therapy alone 6/76 1/5
Chemotherapy alone 26/76 2/5
Chemotherapy plus radiation therapy 2/76 1/5
No treatment 2/76
Unknown 1/76

a Data obtained from 76 out of 100 reported cases were analyzed.

TOOLS
Similar articles