Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells

Sun-yong Hwang; Tae-Hee Kim; Hae-Hyeog Lee; Heung Yeol Kim; Juhyun Seo

doi:10.7180/kmj.2015.30.2.103

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Hwang, Kim, Lee, Kim, and Seo: Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells

Review Article

Kosin Medical Journal 2015;30(2):103-107.

Published online: 20 January 2015

DOI: https://doi.org/10.7180/kmj.2015.30.2.103

Effect of Docosahexaenoic Acid (DHA) on Breast Cancer Cells

Sun-yong Hwang¹, Tae-Hee Kim^2,, Hae-Hyeog Lee², Heung Yeol Kim³, Juhyun Seo⁴

¹Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan, Republic of Korea

²Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University, Bucheon, Republic of Korea

³Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Republic of Korea

⁴Department of Life Science and Biotechnology, Soonchunhyang University College of Natural Sciences, Asan, Republic of Korea

Corresponding Author: Tae-Hee Kim, MD, PhD, Department of Obstetrics and Gynecology, SoonchunhyangUniversity Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do, 14584, Korea TEL: +82-32-621-5380, Fax: +82-2-6008-6874 E-mail: heeobgy@schmc.ac.kr; heeobgy@naver.com

Received 15 September 201515 September 2015 Accepted 16 September 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Today, many materials as drug are developed having various prominent function in order to treatment of disease or cancer. Among these materials, especially docosahexaenoic acid (DHA), main constituents of omega-3 fatty acid, has a lot of beneficial and natural effects, so it has been known as anticancer material especially breast cancer. Breast cancer is disease taking high occurrence level among feminine diseases. DHA has anticancer effects on breast cancer cell, representatively inducing apoptosis, inhibiting proliferation or metastasis. Main effect of DHA on breast cancer cell is apoptosis inducing, which has mechanism that treated DHA causes lipid peroxidation increasing reactive oxygen species (ROS) level and it activates caspase 8 and caspase 9 so activated caspase occurs apoptosis. Cell lines of breast cancer are MDA-MB-231, MCF-7, SK-BR-3, T47D and ZR75. Especially this article uses the MCF-7 cell line at experiment of anti-proliferation by DHA, the MDA-MB-231 cell line at experiment of anti-metastasis by DHA, because that cell line has specialized metastasis activity. Therefore, this paper discusses the effects of natural material DHA as drug of breast cancer.

Keywords: Apoptosis, breast neoplasms, docosahexaenoic acid, metastasis, proliferation

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