Journal List > Kosin Med J > v.28(1) > 1057007

Kosin Med J. 2013 Jun;28(1):35-41. Korean.
Published online June 30, 2013.
Copyright © 2013 Kosin University College of Medicine
The Association Between Serum GGT Level and Bone Mineral Density in Postmenopausal Women
Heung Yeol Kim,1 and Eun Hee Kong2
1Department of Obstetrics and Gynecology, College of Medicine, Kosin University, Busan, Korea.
2Department of Family Medicine, College of Medicine, Kosin University, Busan, Korea.

Corresponding Author: EunHee Kong, Department of Family Medicine, Kosin University College of Medicine, #34, Amnam-dong, Seo-gu, Busan, 602-702, Korea. TEL: 051-990-6365, FAX: 051-990-3045, Email:
Received October 19, 2012; Revised December 06, 2012; Accepted January 02, 2013.



The aim of this study was to identify the relationship between serum gamma-glutamyltransferase (GGT) and bone mineral density (BMD) in postmenopausal women.


We evaluated 200 postmenopausal women who were visiting a health promotion center at a university hospital from January 2009 to December 2011. Their current medical diseases and medication history were collected through medical records. Basic physical examinations and laboratory tests were performed on all subjects.


The levels of serum GGT within their normal range were positively correlated with waist circumference (P = 0.01), triglycerides (P <0.001), alkaline phosphatase (P = 0.009), and uric acid (P = 0.01). The serum GGT within their normal range were negatively associated with the femur neck BMD (P = 0.002). In adjusted analysis including age and body mass index, the BMD of the femur neck was more strongly associated with a high-normal serum GGT level among the postmenopausal women as compared with those with a low-normal serum GGT level (P = 0.02).


Serum GGT within its normal range is negatively correlated with the BMD in the femur neck among postmenopausal women. It can be useful for selecting a group that is at high risk for the bone fracture regardless of the underlying mechanism.

Keywords: Bone mineral density; Gamma-glutamyl transferase; Postmenopause


Table 1
General characteristics. (N=200)
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Table 2
Association with biochemical markers by the quartile of normal serum GGT levels.
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Table 3
Association with biochemical markers by the BMD T-scores of femur neck
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Table 4
Multiple linear regression analysis for associated biochemical markers of BMD T-score of femur neck
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Table 5
Multiple linear regression analysis for associated biochemical markers of BMD T-score of lumbar spine (L1~L4)
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