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Abstract
Objectives
This study was investigated the recovery characteristics of propofol-remifentanil and sevoflurane-remifentanil anesthesia for total thyroidectomy
Methods
Eighty patients in ASA physical status 1 and 2 scheduled for total thyroidectomy were allocated randomly to either group P (n = 40) or group S (n = 40). Anesthesia was maintained with remifentanil effect site concentration (Ce) 1-3 ng/mL and propofol Ce 2-4 μ g/mL in the group P, and was maintained with remifentanil Ce 1-3 ng/mL and sevoflurane 1.5-2% in the group S. Blood pressure, heart rate, and bispectral (BIS) index were measured during perioperative period. The times from discontinuance of anesthetic agent to eye opening, to extubation, and to stating name were measured. Postoperative complications were evaluated.
Objectives
This study was investigated the recovery characteristics of propofol-remifentanil and sevoflurane-remifentanil anesthesia for total thyroidectomy
Methods
Eighty patients in ASA physical status 1 and 2 scheduled for total thyroidectomy were allocated randomly to either group P (n = 40) or group S (n = 40). Anesthesia was maintained with remifentanil effect site concentration (Ce) 1-3 ng/mL and propofol Ce 2-4 μ g/mL in the group P, and was maintained with remifentanil Ce 1-3 ng/mL and sevoflurane 1.5-2% in the group S. Blood pressure, heart rate, and bispectral (BIS) index were measured during perioperative period. The times from discontinuance of anesthetic agent to eye opening, to extubation, and to stating name were measured. Postoperative complications were evaluated.
Results
There were no significant differences between group P and S on the blood pressure, heart rate, and recovery time. BIS index of group P showed lower than that of group S during operation (P < 0.05). The incidences of side effects were similar in the two groups, though the incidence of nausea was higher in the group S (P < 0.05).
REFERENCES
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Fig. 1.
Perioperative changes of mean arterial pressure (MAP). T0, 2 minutes before the induction; T1, right before the endotracheal intubation; T2, right after the endotracheal intubation; T3, right before the beginning of operation; T4, right after the beginning of operation; T5, right before the extubation; T6, postanesthetic care unit (PACU). Group P, propofol and remifentanil; Group S, sevoflurane and remifentanil. Each data was shown as mean ± SD (between groups: P = 0.465).
Fig. 2.
Perioperative changes of heart rate (HR). T0, 2 minutes before the induction; T1, right before the endotracheal intubation; T2, right after the endotracheal intubation; T3, right before the beginning of operation; T4, right after the beginning of operation; T5, right before the extubation; T6, postanesthetic care unit (PACU). Group P, propofol and remifentanil; Group S, sevoflurane and remifentanil. Each data was shown as mean ± SD (between groups: P = 0.691).
Fig. 3.
Perioperative change of bispectral (BIS) index. T0, 2 minutes before the induction; T1, right before the endotracheal intubation; T2, right after the endotracheal intubation; T3, right before the beginning of operation; T4, right after the beginning of operation; T5, right before the extubation. Group P, propofol and remifentanil; Group S, sevoflurane and remifentanil. Each data was shown as mean ± SD (between groups: P = 0.001).
Table 1.
Characteristics of patients
Table 2. Emergence
times from discontinuance of anesthetic drug
| Group P (n = 40) | Group S (n = 40) | |
|---|---|---|
| Time to eye opening (min) | 11.2 ± 2.7 | 10.4 ± 1.9 |
| Time to extubation (min) | 11.9 ± 2.4 | 11.1 ± 1.9 |
| Time to stating name (min) | 14.1 ± 2.2 | 14.5 ± 2.4 |
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