Metastatic Hemangiopericytoma of the Thyroid Gland

Na Ahnsoo; Kwang Kim Seon; Jo Youn Hyun; Sung Park Ho; Hoo Jung Sung

doi:10.11106/jkta.2013.6.2.135

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Ahnsoo, Seon, Hyun, Ho, and Sung: Metastatic Hemangiopericytoma of the Thyroid Gland

Original Article

J Korean Thyroid Assoc 2013;6(2):135-139.

Published online: 3 May 2013

DOI: https://doi.org/10.11106/jkta.2013.6.2.135

Metastatic Hemangiopericytoma of the Thyroid Gland

Na Ahnsoo, Kwang Kim Seon, Jo Youn Hyun, Sung Park Ho, Hoo Jung Sung

¹Department of Surgery, Chonbuk National University Medical School, Jeonju, Korea

²Department of Pathology, Chonbuk National University Medical School, Jeonju, Korea

³Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea

Address reprint requests to Hyun Jo Youn, MD, PhD, Division of Breast Thyroid Surgery, Department of Surgery, Chonbuk National University Medical School, 634-18 Geumam-dong, Deukjin-gu, Jeonju 561-712, Korea Tel: 82-63-250-2389, Fax: 82-63-271-6197, E-mail: yhj0903@jbnu.ac.kr

Received 5 August 2013 Accepted 9 November 2013

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hemangiopericytoma (HPC) is a mesenchymal neoplasm constituting a minor portion of vascular tumors. Although HPCs are generally benign, some progress in a malignant course, leading to recurrence and metastasis even after radical surgery. We present a case of metastatic HPC of the thyroid gland, a very rare site of occurrence. Histological findings revealed a single, well-margined mass with high cellularity. Tumor cells were tightly packed spindle-shaped to round cells arranged around numerous thin-walled vessels. Tumor cells showed cytoplasmic immunoreactivity for CD34 and CD99. To our knowledge, this is the eleventh case reported worldwide and the first case in South Korea.

Keywords: Hemangiopericytoma, Thyroid, Metastasis, Solitary fibrous tumor

References

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Fig. 1.

Preoperative chest computed tomography. A 3.3X2.6 -cm-sized, well-circumscribed, round mass was observed within the left lobe of the thyroid. The mass showed heterogeneous enhancement on contrast phase. Calcification was not observed, and there was no evidence of adjacent tissue invasion.

Fig. 2.

Gross findings of the thyroid mass. A 3.6X3.2–cm-sized mass was observed within the left lobe of the thyroid. The mass was yellowish-white in color, relatively soft, and well-defined.

Fig. 3.

Microscopic findings of the thyroid mass. (A) Low-power view of the thyroid revealed a well–marginated, encapsulated mass with evenly distributed cellularity (H & E, X40). (B) Tumor cells were tightly packed and arranged around numerous thin-walled vessels. The cells were spindle-shaped to round and of uniform size, with small amounts of pale or eosinophilic cytoplasm with indistinct margins (H & E, X200). (C) Tumor cells revealed cytoplasmic immunoreactivity for CD34 (CD34, X200). Delicate, branching vessels were accentuated. (D) Tumor cells revealed cytoplasmic immunoreactivity for CD99 (CD99, X200).

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