Two Cases of Non-Small Cell Lung Cancer Masquerading as Metastatic Papillary Thyroid Cancer

Ju Hee Lee; Se-Hoon Lee; Hye Sook Min; Ji-hoon Kim; Do Joon Park; Young Joo Park

doi:10.11106/jkta.2012.5.2.157

Journal List > J Korean Thyroid Assoc > v.5(2) > 1056511

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Lee, Lee, Min, Kim, Park, and Park: Two Cases of Non-Small Cell Lung Cancer Masquerading as Metastatic Papillary Thyroid Cancer

Case Report

Journal of Korean Thyroid Association

Journal of Korean Thyroid Association 2012; 5(2): 157-160.

Published online: 28 November 2012

DOI: https://doi.org/10.11106/jkta.2012.5.2.157

Two Cases of Non-Small Cell Lung Cancer Masquerading as Metastatic Papillary Thyroid Cancer

Ju Hee Lee¹, Se-Hoon Lee², Hye Sook Min³, Ji-hoon Kim⁴, Do Joon Park², Young Joo Park²

¹Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea.

²Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

³Department of Pathology Seoul National University College of Medicine, Seoul, Korea.

⁴Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.

Correspondence: Young Joo Park, MD, PhD, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea. Tel: 82-2-2072-4183, Fax: 82-2-764-2199, yjparkmd@snu.ac.kr

Received 22 September 2012 Revised 16 October 2012 Accepted 16 October 2012

(open-access):

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Papillary thyroid carcinoma and primary lung cancer have vastly different treatment approaches and prognosis. If lung mass is found in patients with papillary thyroid carcinoma, we have to be aware of the possibility of primary lung cancer especially when the lesion is not iodine-avid, or is not typical to metastatic thyroid carcinoma, or serum thyroglobulin is not elevated. Here we present two cases of non-small cell lung cancer masquerading as metastatic papillary thyroid carcinoma and think of the approach of the lung mass which is found in patients with papillary thyroid carcinoma.

Keywords: Nepolasm metastasis, Papillary thyroid carcinoma, Non-small-cell lung carcinoma

Figures and Tables

Fig. 1

(A) 0.9 cm sized hypoechoic nodule at the operation bed (arrow) was found on neck ultrasonogram. (B) Chest CT showed 2.4 cm sized nodule (arrow) in left upper lobe lingular division. (C) Bone scan revealed multiple increased uptake in skull, T-L spines, both ribs, left scapula, left humerus, left radius, left pelvic bone and left femur. (D) The lung biopsy was diagnosed as primary well-differentiated adenocarcinoma (H&E stain, ×200).

Fig. 2

(A) Neck ultrasonography showed metastatic lymph nodes (arrow) in left neck level VI. (B) L-spine MRI showed L2 compression fracture (arrow). (C) Chest CT showed diffuse irregular pleural thickening with pleural masses (arrow) in left hemithorax. (D) The lung needle biopsy was non small cell carcinoma focally showing gland-forming features, which was suggestive of adenocarcinoma of lung (H&E stain, ×400).

References

1. The Korea Central Cancer Registry. National Cancer Center. Annual report of cancer statistics in Korea in 2008. 2010. Seoul, Korea: Ministry of Health and Welfare.

2. Lee YJ, Han JY. Current trends in early diagnosis and treatment of lung cancer. Korean J Med. 2011. 80(5):529–531.

3. Sipos JA, Mazzaferri EL. Thyroid cancer epidemiology and prognostic variables. Clin Oncol (R Coll Radiol). 2010. 22(6):395–404.

4. Sampson E, Brierley JD, Le LW, Rotstein L, Tsang RW. Clinical management and outcome of papillary and follicular (differentiated) thyroid cancer presenting with distant metastasis at diagnosis. Cancer. 2007. 110(7):1451–1456.

5. Lee J, Soh EY. Differentiated thyroid carcinoma presenting with distant metastasis at initial diagnosis clinical outcomes and prognostic factors. Ann Surg. 2010. 251(1):114–119.

6. Yi KH, Park YJ, Koong SS, Kim JH, Na DG, Ryu JS, et al. Revised Korean Thyroid Association management guidelines for patients with thyroid nodules and thyroid cancer. Endocrinol Metab. 2010. 25(4):270–297.

7. Lind P, Kohlfurst S. Respective roles of thyroglobulin, radioiodine imaging, and positron emission tomography in the assessment of thyroid cancer. Semin Nucl Med. 2006. 36(3):194–205.

8. Lin JD, Chao TC, Chou SC, Hsueh C. Papillary thyroid carcinomas with lung metastases. Thyroid. 2004. 14(12):1091–1096.

TOOLS

Similar articles