In vivo quantitative analysis of remineralization effect of remineralization solution

Myung-Eun Kim; Il-young Jung; Kee-Yeon Kum; Chang-young Lee; Byoung-Duck Roh

doi:10.5395/JKACD.2002.27.2.175

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Kim, Jung, Kum, Lee, and Roh: In vivo quantitative analysis of remineralization effect of remineralization solution "R" of incipient enamel dental caries

Original Article

Journal of Korean Academy of Conservative Dentistry

Journal of Korean Academy of Conservative Dentistry 2002; 27(2): 175-182.

Published online: 31 March 2002

DOI: https://doi.org/10.5395/JKACD.2002.27.2.175

In vivo quantitative analysis of remineralization effect of remineralization solution "R" of incipient enamel dental caries

Myung-Eun Kim, Il-young Jung, Kee-Yeon Kum, Chang-young Lee, Byoung-Duck Roh

Department of Conservative Dentistry, college of dentistry, Yonsei University, Korea.

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dental caries is a chronic disease that causes the destruction of tooth structure by the interaction of plaque bacteria, food debris, and saliva.

There has been attempts to induce remineralization by supersaturating the intra-oral environment around the surface enamel, where there is incipient caries.

In this study, supersaturated remineralized solution "R" was applied to specimens with incipient enamel caries, and the quantitative ananlysis of remineralization was evaluated using microradiography. Thirty subjects volunteered to participate in this study. Removable appliances were constructed for the subjects, and the enamel specimen with incipient caries were embedded in the appliances. The subjects wore the intra-oral appliance for 15 days except while eating and sleeping.

The removable appliance were soaked in supersaturated solution "R", saline, or Senstime® to expose the specimen to those solutions three times a day, 5 minutes each time. After 15 days, microradiography was retaken to compare and evaluate remineralization.

The results were as the following:

1. The ratio of remineralized area to demineralized area was significantly higher in the supersaturated solution "R" and Senstime® than in the saline. (p<0.05)

2. Remineralization in the supersaturated buffer solution "R" occurred in the significantly deeper parts of the tooth, compared to the Senstime® group containing high concentration of fluoride.(p<0.05)

As in the above results, the remineralization effect of remineralized buffer solution "R" on incipient enamel caries has been proven. For clinical utilization, further studies on soft tissue reaction and the effect on dentin and cementum are necessary.

In conclusion compared to commercially available fluoride solution, remineralization solution "R" showed better remineralization effect on early enamel caries lesion, so it is considered as effecient solution for clinical application.

Keywords: Enamel caries, Remineralization solution, Remineralization, Removable oral appliance, Microradiography

Figures and Tables

Fig. 1

Drawing of enamel specimen

Fig. 2

Removable oral appliance attached with demineralized enamel specimen

Fig. 3

Quantitative mineral volume change(%) of enamel

Fig. 4

Average mineral volume change of enamel specimen with remineralization solution "R"

Fig. 5

Average mineral voulme change of enamel specimen with saline

Fig. 6

Average mineral voulme change of enamel specimen with Senstime

Table 1

Initial composition of demineralization solution

Table 2

Initial composition of remineralization solution

Table 3

Experimental solution

Table 4

Remineralization peak depth from the surface

^*significantly different(p<0.05)

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