Lessons from Recent Cardiovascular Outcome Trials of Type 2 Diabetes

Nam Hoon Kim; Sin Gon Kim

doi:10.4093/jkd.2017.18.1.7

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Kim and Kim: Lessons from Recent Cardiovascular Outcome Trials of Type 2 Diabetes

Statement

J Korean Diabetes 2017;18(1):7-13.

Published online: 10 January 2017

DOI: https://doi.org/10.4093/jkd.2017.18.1.7

Lessons from Recent Cardiovascular Outcome Trials of Type 2 Diabetes

Nam Hoon Kim, Sin Gon Kim

Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea

Corresponding author: Sin Gon Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 73 Inchon-ro, Seongbuk-gu, Seoul 02841, Korea, E-mail: k50367@korea.ac.kr

Received 6 February 2017 Accepted 27 February 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Since the US Food and Drug Administration issued guidance requiring cardiovascular safety for all antidiabetic drugs in 2008 (US FDA industry guidance for licensing of antidiabetic drugs), the number of cardiovascular outcome trials in diabetes has remarkably increased. Cardiovascular outcome trial is considered a gold standard for establishing the cardiovascular safety of antidiabetic agents. However, there are possible limitations in information gained from cardiovascular outcome trials and other issues such as cost. In this review, we summarize recent cardiovascular outcome trials in type 2 diabetes and provide an overview of the implications and limitations of those trials.

Keywords: Cardiovascular disease, Diabetes mellitus, Randomized controlled trial, Type 2

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