Drug-Induced Diabetes Mellitus

Dongwon Yi; Yang Ho Kang

doi:10.4093/jkd.2017.18.3.160

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Yi and Kang: Drug-Induced Diabetes Mellitus

Focused Issue

J Korean Diabetes 2017;18(3):160-168.

Published online: 10 January 2017

DOI: https://doi.org/10.4093/jkd.2017.18.3.160

Drug-Induced Diabetes Mellitus

Dongwon Yi, Yang Ho Kang

Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea

Corresponding author: Yang Ho Kang Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20 Geumo-ro, Mulgeum-eup, Yangsan 50612, Korea, E-mail: kangyh@pusan.ac.kr

Received 8 August 2017 Accepted 10 August 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Drug-induced diabetes is becoming more prevalent as a result of individuals taking diverse types of medication. A variety of drugs can impair glucose tolerance through several mechanisms, including increased insulin resistance, diminished insulin secretion, or both. Efforts should be made to identify and closely monitor patients receiving drugs that may alter glucose metabolism as diabetes is a leading cause of morbidity and mortality. We review the latest data concerning commonly used drugs associated with development of diabetes and present postulated mechanisms by which the drugs might cause diabetes.

Keywords: Diabetes mellitus, Drug-related side effects and adverse reactions, Hyperglycemia, Metabolic side effects of drugs and substances

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Table 1.

Drugs associated with development of diabetes and their suggested mechanisms

Mechanisms	Drugs
Insulin resistance and diminished insulin secretion	Glucocorticoids
	Thiazide diuretics
	Beta-blockers
	Statins
	Nicotinic acid
	Atypical antipsychotics
	Protease inhibitors
Insulin resistance	Oral contraceptives
	Beta-agonists
	Growth hormone
	Megestrol
Diminished insulin secretion	Fluoroquinolones
	Diazoxide
	Phenytoin
	Calcineurin inhibitors
	Didanosine
	Pentamidine L-asparaginase

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