Recent Advances for Anti-Obesity Agents

Chul Sik Kim

doi:10.4093/jkd.2015.16.4.260

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Kim: Recent Advances for Anti-Obesity Agents

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J Korean Diabetes 2015;16(4):260-268.

Published online: 10 January 2015

DOI: https://doi.org/10.4093/jkd.2015.16.4.260

Recent Advances for Anti-Obesity Agents

Chul Sik Kim

Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea

Corresponding author: Chul Sik Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea, E-mail: ironeat@gmail.com

Received 9 November 2015 Accepted 13 November 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Obesity is one of the most significant risk factor for diabetes, cardiovascular disease, malignancy and other chronic diseases. The obesity and its associated conditions is one of the most urgent health concerns worldwide. Lifestyle modifications comprising diet modification, exercise, and behavior therapy are basic to the treatment for obesity. However, it has become apparent that lifestyle modifications alone will not be enough for many patients with obesity. Therefore, apractical approach includes consideration of pharmacotherapeutic options. Until 2012, orlistat was the only approved medication for long-term obesity management. In 2012, lorcaserin and phentermine/topiramate were approved by the USA Food and Drug Administration as new anti-obesity drugs, and in 2014, two additional medications were added, naltrexone/bupropion and liraglutide. This review discusses the different pharmacotherapeutic options for the treatment of obesity.

Keywords: Anti-obesity agents, Obesity

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Fig. 1.

Change in bodyweight for 56 weeks of naltrexone plus bupropion treatment. Revised from the article of Greenway et al (Lancet 2010;376:595–605) [31] with original copyright holder's permission. article of Greenway, et al. (Lancet. 2010;376:595–605) [31] with original copyright holder's permission. Fig. 1. Change in bodyweight for 56 weeks of naltrexone plus bupropion treatment. Revised from the

Table 1.

USA FDA approved anti-obesity medications in Korea and DEA schedules

Generic name	DEA schedule	Approved use	Dosage
Orlistat	None	Long-term	120 mg tid
Diethylpropion	IV	Short-term	25 mg tid
Phentermine	IV	Short-term	15∼37.5 mg sid
Mazindol	IV	Short-term	1 mg sid∼tid
Phendimetrazine	III	Short-term	35 mg tid
Lorcaserin	IV	Long-term	10 mg sid

FDA, Food and Drug Administration; DEA, Drug Enforcement Agency; tid, three times a day; sid: once a day.

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