Clinical Use of New Insulins and New Insulin Delivery Systems

Tae-Seok Lim; Seung-Hyun Ko

doi:10.4093/jkd.2015.16.4.242

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Lim and Ko: Clinical Use of New Insulins and New Insulin Delivery Systems

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J Korean Diabetes 2015;16(4):242-251.

Published online: 10 January 2015

DOI: https://doi.org/10.4093/jkd.2015.16.4.242

Clinical Use of New Insulins and New Insulin Delivery Systems

Tae-Seok Lim, Seung-Hyun Ko

Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

Corresponding author: Seung-Hyun Ko Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea, St. Vincent's Hospital, 93 Jungbu-daero, Paldal-gu, Suwon 16247, Korea, E-mail: kosh@catholic.ac.kr

Received 29 October 2015 Accepted 5 November 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Insulin plays an important role in the treatment of diabetes. Since it was discovered in the early 1920s, major advances have been made in the medical use of insulin. However, certain insulin associated challenges remain, such as hypoglycemia, weight gain, complex management, and injection site pain. Novel insulins and delivery systems are being developed that can address these limitations. Insulin degludec is a novel basal insulin with a long half-life (25 hours) and action duration (> 42 hours). Glargine U300 is a concentrated formulation of insulin glargine. For improvement in postprandial glucose control, ultrarapid-acting insulins are being investigated. New insulin delivery systems including inhaled insulin and insulin patches are also being developed to overcome the inconvenience associated with subcutaneous injection. In this review, clinical studies of new insulins and new insulin delivery systems are summarized.

Keywords: Diabetes mellitus, Insulin, Insulin delivery system

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Table 1.

Comparison of novel basal insulins

Basal insulin	Degludec	Glargine U300
Half-life (h)	25	19
Drug action duration (h)	42	36
Units per mL	100	300
Drug content of one pen	300 U/3 mL	450 U/1.5 mL
Storage conditions of an opened pen	Below 30℃ for 8 weeks	Below 30℃ for 6 weeks

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