Circadian Rhythm Disruption and Metabolic Syndrome

Daham Kim; Young Suk Jo

doi:10.4093/jkd.2014.15.4.216

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Kim and Jo: Circadian Rhythm Disruption and Metabolic Syndrome

Focused Issue – Variability

J Korean Diabetes 2014;15(4):216-220.

Published online: 20 January 2014

DOI: https://doi.org/10.4093/jkd.2014.15.4.216

Circadian Rhythm Disruption and Metabolic Syndrome

Daham Kim¹, Young Suk Jo²

¹Department of Biochemistry and Molecular Biology

²Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Metabolic syndrome is a complex disorder and an emerging clinical challenge. It is induced by the interplay of genetic and environmental factors. Recently, evidence has emerged to suggest that circadian rhythm disruption is a new risk factor to explain the increased incidence of metabolic syndrome. This review summarizes circadian rhythm biology and the evidence linking circadian rhythm disruptions to metabolic syndrome, as related to lipid metabolism, glucose homeostasis, and cardiovascular function. Further understanding of circadian rhythm will aid the development of novel therapeutic strategies for metabolic syndrome.

Keywords: Circadian rhythm, Metabolic syndrome, Obesity, Diabetes mellitus, Cardiovascular disease

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Fig. 1.

Schematic summary of the core molecular clock related to circadian rhythm. Adapted from Sheikh-Ali M et al. Postgrad Med J 2014;90:461–6 [38].

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