Glucose Lowering Effect of SGLT2 Inhibitors: A Review of Clinical Studies

Hae Jin Kim

doi:10.4093/jkd.2014.15.3.146

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Kim: Glucose Lowering Effect of SGLT2 Inhibitors: A Review of Clinical Studies

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J Korean Diabetes 2014;15(3):146-150.

Published online: 7 January 2014

DOI: https://doi.org/10.4093/jkd.2014.15.3.146

Glucose Lowering Effect of SGLT2 Inhibitors: A Review of Clinical Studies

Hae Jin Kim

Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea

교신저자: 김혜진, 경기도 수원시 영통구 월드컵로 206 아주대학교병원 내분비대사내과, E-mail: jinkim@ajou.ac.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There are numerous glucose lowering agents in clinical use for type 2 diabetic patients, yet most do not achieve glycemic targets. Recently, inhibitors of the sodium glucose cotransporter 2 (SGLT2) have been developed, which show great potential of being a novel therapeutic option to treat type 2 diabetes. Many researches have turned their attention to the kidney as a target because renal glucose reabsorption is increased in type 2 DM. SGLT2 is a protein transporter that mediates glucose reabsorption from glomerular filtrates. In an insulin-independent manner, inhibition of SGLT2 increases urinary glucose excretion and decreases plasma glucose levels. To date, there are a few SGLT2 inhibiting agents being clinically studied both as a monotherapy and in combination with other antidiabetic agents. This review will focus on the efficacy of SGLT2 inhibitors based on clinical studies.

Keywords: Hypoglycemic agents, Sodium glucose cotransporter 2, Type 2 diabetes mellitus

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Fig. 1.

Changes in glycated hemoglobin (HbA1C) in trials with sodium glucose cotransporter 2 inhibitors. PBO, placebo. Adapted from Fujita Y et al. J Diabetes Investig. 2014;5:265-75[3].

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