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Rhee: The Role of the Kidney in Glucose Metabolism
Focused Issue

J Korean Diabetes 2014;15(3):142-145.

Published online: 7 January 2014

DOI: https://doi.org/10.4093/jkd.2014.15.3.142

The Role of the Kidney in Glucose Metabolism

Sang Youl Rhee

Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea

교신저자: 이상열, 서울시 동대문구 경희대로 23 경희의료원 내분비내과, E-mail: bard95@hanmail.net

Copyright © 2014 Korean Diabetes Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It is well known that the kidney is important for maintaining glucose homeostasis in vivo. However, the physiological role of the kidney in glucose metabolism is typically underestimated. Recently, a new class of anti-diabetic medications that affect the renal glucose regulatory mechanism was introduced into the market, sparking the interest of many researchers to better understand this mechanism. In this article, I briefly describe the role of the kidney in glucose metabolism and the changes of its function in patients with diabetes mellitus.

Keywords: Kidney, Glucose, Type 2 diabetes mellitus, Sodium glucose cotransporter 2, Gluconeogenesis

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Fig. 1.
Sodium glucose cotransporters (SGLTs) in the kidney. Adapted from Santer R, et al. Clin J Am Soc Nephrol 2010;5:133-41[12].
jkd-15-142f1.tif
Table 1.
The sodium glucose cotransporter family.
Co-transporter Gene Distribution Substrate
SGLT1 SLC5A1 Intestine, trachea, kidney, heart, brain, testis, prostate Glucose, galactose
SGLT2 SLC5A2 Kidney, brain, liver, thyroid, muscle, heart Glucose
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