Journal List > J Korean Diabetes > v.14(2) > 1054912

Kim, Kim, Park, Ko, Byun, Hong, Lee, Nam-Goong, Kim, Na, Choi, and Kwon: A Case of Insulinoma with Hypoglycemic Encephalopathy

Abstract

A 47-year-old male with recurrent abnormal behavior for ten years was referred to our clinic. He was diagnosed with insulinoma and cognitive dysfunction. Persistent hypoglycemia leads to a high risk of cognitive dysfunction in diabetic patients. However, cognitive dysfunction associated with insulinoma is rare. In this case study, cognitive dysfunction was confirmed by neurological testing.

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Fig. 1.
(A) Pancreas computed tomography scan showing an enhanced 8-mm nodule in the superior aspect of the pancreas body. (B) Transhepatic portal venous sampling revealed an elevated serum insulin level (662.7 μU/mL) in the body of the pancreas.
jkd-14-98f1.tif
Fig. 2.
Microscopically, the tumor showed a solid, trabecular, and gyriform growth pattern. The tumor cells had small and relatively uniform nuclei with a granular cytoplasm. Hyalinized stroma with calcification are seen (H&E, x200).
jkd-14-98f2.tif
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