Bone and Energy Metabolism

Sujin Lee; Yumie Rhee

doi:10.4093/jkd.2013.14.4.174

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Lee and Rhee: Bone and Energy Metabolism

Focused Issue

J Korean Diabetes 2013;14(4):174-177.

Published online: 10 January 2013

DOI: https://doi.org/10.4093/jkd.2013.14.4.174

Bone and Energy Metabolism

Sujin Lee, Yumie Rhee

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bone remodeling requires a large amount of energy, and is regulated by various hormones. Leptin, produced by adipocytes, is a well-known regulator of energy balance and is also involved in controlling bone mass through interaction with the central nervous system. Serotonin, downstream of leptin, is also emerging as a candidate for controlling energy balance and bone metabolism. Currently, bone is also considered to be an endocrine regulator of energy metabolism. Osteocalcin, secreted from osteoblasts, is known to be a key regulator of glucose and fat metabolism. In this review, we describe a novel concept that asserts that there exists a biological link between bone and energy metabolism, and we summarize what is currently known about the relationship between bone and energy metabolism.

Keywords: Bone, Energy metabolism, Leptin, Serotonin, Neurotransmitter agents, Osteocalcin

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