Insulin Autoimmune Syndrome with Diabetic Ketoacidosis

Yeong Geol Jo; Young Il Kim; Su Jin Lee; Ki Won Kim; Sung Wan Chun; Yeo Joo Kim; Sang Jin Kim

doi:10.4093/jkd.2012.13.2.105

Journal List > J Korean Diabetes > v.13(2) > 1054826

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Jo, Kim, Lee, Kim, Chun, Kim, and Kim: Insulin Autoimmune Syndrome with Diabetic Ketoacidosis

Original Articles & Case Reports

The Journal of Korean Diabetes

The Journal of Korean Diabetes 2012; 13(2): 105-109.

Published online: 30 June 2012

DOI: https://doi.org/10.4093/jkd.2012.13.2.105

Insulin Autoimmune Syndrome with Diabetic Ketoacidosis

Yeong Geol Jo, Young Il Kim, Su Jin Lee, Ki Won Kim, Sung Wan Chun, Yeo Joo Kim, Sang Jin Kim

Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, Korea.

Corresponding author (yeojoo@schmc.ac.kr)

Abstract

Insulin autoimmune syndrome is characterized by spontaneous hypoglycemia, elevated insulin level and a high level of insulin autoantibodies without previous insulin exposure. Among the clinical manifestations of insulin autoimmune syndrome, diabetic ketoacidosis is extremely rare. A 72-year-old diabetic woman was hospitalized with diabetic ketoacidosis. She suffered repeated fasting hypoglycemia after treatment of the diabetic ketoacidosis. Here we describe this case of insulin autoimmune syndrome manifested as diabetic ketoacidosis followed by recurrent hypoglycemia with a review of the relevant literature.

Keywords: Diabetic ketoacidosis, Hypoglycemia, Insulin autoantibody

Figures and Tables

Fig. 1

This figure shows that hypoglycemia was occurred at 360 min of 75 g oral glucose tolerance test.

Fig. 2

Abdominal computed tomography scan shows no evidence of any pancreatic mass.

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