Diabetic foot disease is a major health problem affecting people with diabetes in developed countries, as well as in many developing countries. In people with diabetes the lifetime risk of developing diabetic foot ulcer is about 25%, and this risk may be increased in elderly people with type 2 diabetes. Although the prevalence and severity of diabetic foot disease varies in different regions, peripheral neuropathy is the common pathway leading to ulceration or diabetic foot disease across regions. The pathogenesis and related factors of diabetic foot disease are briefly described in this report.