Abstract
Diabetes is a common medical condition in hospitalized patients and is associated with increased requirement for operation and increased postoperative morbidity and mortality. The stress of surgery induces catabolic changes that alter glucose and lipid levels, as well as protein metabolism. Persistent hyperglycemia can lead to ketoacidosis in type I diabetic patients or hyperosmolar syndrome in type 2 diabetic patients. Also, hyperglycemia is a risk factor for endothelial dysfunction, impaired immunity, wound healing and embolism. The ultimate goal in the management of diabetic patients is to optimize glucose control through monitoring, fluid replacement and use of insulin.
REFERENCES
1. Goldmann DR. Surgery in patients with endocrine dysfunction. Med Clin North Am. 1987; 71:499–509.
2. Galloway JA, Shuman CR. Diabetes and surgery. A study of 667 cases. Am J Med. 1963; 34:177–91.
3. Rayfield EJ, Ault MJ, Keusch GT, Brothers MJ, Nechemias C, Smith H. Infection and diabetes: the case for glucose control. Am J Med. 1982; 72:439–50.
4. Halter JB, Pflug AE. Relationship of impaired insulin secretion during surgical stress to anesthesia and catecholamine release. J Clin Endocrinol Metab. 1980; 51:1093–8.
5. Clarke RS, Johnston H, Sheridan B. The influence of anaesthesia and surgery on plasma cortisol, insulin and free fatty acids. Br J Anaesth. 1970; 42:295–9.
6. Halter JB, Pflug AE, Porte D Jr. Mechanism of plasma catecholamine increases during surgical stress in man. J Clin Endocrinol Metab. 1977; 45:936–44.
7. Hempel A, Maasch C, Heintze U, Lindschau C, Dietz R, Luft FC, Haller H. High glucose concentrations increase endothelial cell permeability via activation of protein kinase C alpha. Circ Res. 1997; 81:363–71.
8. Russell RC, Walker CJ, Bloom SR. Hyperglucagonaemia in the surgical patient. Br Med J. 1975; 1:10–2.
9. Newsome HH, Rose JC. The response of human adrenocorticotrophic hormone and growth hormone to surgical stress. J Clin Endocrinol Metab. 1971; 33:481–7.
10. Burgos LG, Ebert TJ, Asiddao C, Turner LA, Pattison CZ, Wang-Cheng R, Kampine JP. Increased intraoperative cardiovascular morbidity in diabetics with autonomic neuropathy. Anesthesiology. 1989; 70:591–7.
11. Chen S, Anderson MV, Cheng WK, Wongworawat MD. Diabetes associated with increased surgical site infections in spinal arthrodesis. Clin Orthop Relat Res. 2009; 467:1670–3.
12. Mraovic B, Suh D, Jacovides C, Parvizi J. Perioperative hyperglycemia and postoperative infection after lower limb arthroplasty. J Diabetes Sci Technol. 2011; 5:412–8.
13. Zerr KJ, Furnary AP, Grunkemeier GL, Bookin S, Kanhere V, Starr A. Glucose control lowers the risk of wound infection in diabetics after open heart operations. Ann Thorac Surg. 1997; 63:356–61.
14. Liu BF, Miyata S, Kojima H, Uriuhara A, Kusunoki H, Suzuki K, Kasuga M. Low phagocytic activity of resident peritoneal macrophages in diabetic mice: relevance to the formation of advanced glycation end products. Diabetes. 1999; 48:2074–82.
15. Marhoffer W, Stein M, Maeser E, Federlin K. Impairment of polymorphonuclear leukocyte function and metabolic control of diabetes. Diabetes Care. 1992; 15:256–60.
16. Schiekofer S, Balletshofer B, Andrassy M, Bierhaus A, Nawroth PP. Endothelial dysfunction in diabetes mellitus. Semin Thromb Hemost. 2000; 26:503–11.
17. Lee KM, Lee KC, Lee SY, Woo NS, Lee YC. Evaluation of the effects of diabetes on preoperative and postoperative patients' status with blood glucose level, arterial blood gas, and alveolar-arterial O2 tension difference. Korean J Anesthesiol. 2004; 47:488–92.
18. Bohlen HG. Mechanisms for early microvascular injury in obesity and type II diabetes. Curr Hypertens Rep. 2004; 6:60–5.
19. Lee HZ, Yeh FT, Wu CH. The effect of elevated extracellular glucose on adherens junction proteins in cultured rat heart endothelial cells. Life Sci. 2004; 74:2085–96.
20. Wass CT, Lanier WL. Glucose modulation of ischemic brain injury: review and clinical recommendations. Mayo Clin Proc. 1996; 71:801–12.
21. Weekers F, Giulietti AP, Michalaki M, Coopmans W, Van Herck E, Mathieu C, Van den Berghe G. Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. Endocrinology. 2003; 144:5329–38.
22. Indermitte J, Burkolter S, Drewe J, Kr?henb?hl S, Hersberger KE. Risk factors associated with a high velocity of the development of hyperkalaemia in hospitalised patients. Drug Saf. 2007; 30:71–80.
23. Carraro M, Mancini W, Artero M, Zennaro C, Faccini L, Candido R, Armini L, Calci M, Carretta R, Fabris B. Albumin permeability in isolated glomeruli in incipient experimental diabetes mellitus. Diabetologia. 2000; 43:235–41.
24. D'Erasmo E, Pisani D, Ragno A, Raejntroph N, Vecci E, Acca M. Calcium homeostasis during oral glucose load in healthy women. Horm Metab Res. 1999; 31:271–3.