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Sohn, Hwang, Song, and Lim: A Case of Hyponatremia Associated with Paroxetine -A case report-
Case Report
Brain & Neurorehabilitation

Brain & Neurorehabilitation 2012; 5(1): 43-46.

Published online: 31 March 2012

DOI: https://doi.org/10.12786/bn.2012.5.1.43

A Case of Hyponatremia Associated with Paroxetine -A case report-

Min-Kyun Sohn, M.D., Seon-Lyul Hwang, M.D., Hyun-Tak Song, M.D., Jun-Ho Lim, M.D.

Department of Rehabilitation Medicine, School of Medicine, Chungnam National University, Korea.

Corresponding author (ljh2434@cnuh.co.kr)

Received 15 July 2011       Revised 21 October 2011       Accepted 24 October 2011

Copyright © 2012 Korea Society for Neurorehabilitation

Abstract

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) widely used for depression in brain damaged patients as it is known for its few affects on cognition or psychomotor function. Major side effects observed for paroxetine are vertigo, headache and tremor. It is reported that hyponatremia is also rarely observed. In 69 year-old male with left hemiplegia due to cerebral infarction had started taking 20 mg/day of paroxetine for depression. Next day the patient showed severe generalized weakness and decreased consciousness. Laboratory tests showed that serum sodium level was decreased to 102 mEq/L. Paroxetine administration was stopped and 3% sodium and oral furosemide were administered under the diagnosis of syndrome of inappropriate secretion of antidiuretic hormone (SIADH). We report a case of patient with severe hyponatremia due to SIADH within 2 days after use of paroxetine. This case emphasizes the need to monitor serum sodium level routinely at the initial treatment to prevent hyponatremia.

Keywords: hyponatremia, paroxetine, SIADH

Figures and Tables

Fig. 1
Axial DWI image shows focal cerebral infarction in right precentral gyrus.
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Fig. 2
Changes of serum sodium level after paroxetine medication.
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