References
1. McDonald MP, Overmier JB. Present imperfect: a critical review of animal models of the mnemonic impairments in alzheimer's disease. Neurosci Biobehav Rev. 1998. 22:99–120.
2. Yamada K, Nabeshima T, Kameyama T. Impairment of active avoidance response in rats with continuous infusion of quinolinic acid into the lateral ventricle. J Pharmacobiodyn. 1991. 14:351–355.
3. Itoh A, Nitta A, Katono Y, Usui M, Naruhashi K, Iida R, Hasegawa T, Nabeshima T. Effects of metrifonate on memory impairment and cholinergic dysfunction in rats. Eur J Pharmacol. 1997. 322:11–19.
4. Kinoshita H, Kameyama T, Hasegawa T, Nabeshima T. Effects of vinconate on spatial learning impairments induced by medial septal lesion in rats. Life Sci. 1992. 51:267–273.
5. Misztal M, Frankiewicz T, Parsons CG, Danysz W. Learning deficits induced by chronic intraventricular infusion of quinolinic acid--protection by mk-801 and memantine. Eur J Pharmacol. 1996. 296:1–8.
6. Nabeshima T, Nitta A, Fuji K, Kameyama T, Hasegawa T. Oral administration of ngf synthesis stimulators recovers reduced brain ngf content in aged rats and cognitive dysfunction in basal-forebrain-lesioned rats. Gerontology. 1994. 40:Suppl 2. 46–56.
7. Bigl V, Schliebs R. Simulation of cortical cholinergic deficits--a novel experimental approach to study pathogenetic aspects of alzheimer's disease. J Neural Transm Suppl. 1998. 54:237–247.
8. Waite JJ, Chen AD, Wardlow ML, Wiley RG, Lappi DA, Thal LJ. 192 immunoglobulin g-saporin produces graded behavioral and biochemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar purkinje cells. Neuroscience. 1995. 65:463–476.
9. Nitta A, Murase K, Furukawa Y, Hayashi K, Hasegawa T, Nabeshima T. Memory impairment and neural dysfunction after continuous infusion of anti-nerve growth factor antibody into the septum in adult rats. Neuroscience. 1993. 57:495–499.
10. Nitta A, Ogihara Y, Onishi J, Hasegawa T, Furukawa S, Nabeshima T. Propentofylline prevents neuronal dysfunction induced by infusion of anti-nerve growth factor antibody into the rat septum. Eur J Pharmacol. 1996. 307:1–6.
11. Nabesima TA, Itoh A. Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM, editors. Toxicity of β-amyloid protein: Neurochemical, histological and behavioral changes. Alzheimer's Disease: Biology, Diagnosis and Therapeutics. 1997. Chichester: Wiley;623–630.
12. Yamada K, Ren X, Nabeshima T. Perspectives of pharmacotherapy in alzheimer's disease. Jpn J Pharmacol. 1999. 80:9–14.
13. Kowall NW, Beal MF, Busciglio J, Duffy LK, Yankner BA. An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance p. Proc Natl Acad Sci U S A. 1991. 88:7247–7251.
14. Harkany T, O'Mahony S, Kelly JP, Soos K, Toro I, Penke B, Luiten PG, Nyakas C, Gulya K, Leonard BE. Beta-amyloid (phe(so3h)24)25-35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation. Behav Brain Res. 1998. 90:133–145.
15. Geula C, Wu CK, Saroff D, Lorenzo A, Yuan M, Yankner BA. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med. 1998. 4:827–883.
16. Flood JF, Morley JE, Roberts E. Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with alzheimer disease. Proc Natl Acad Sci USA. 1991. 88:3363–3366.
17. Moran PM, Higgins LS, Cordell B, Moser PC. Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein. Proc Natl Acad Sci U S A. 1995. 92:5341–5345.
18. Irizarry MC, Soriano F, McNamara M, Page KJ, Schenk D, Games D, Hyman BT. Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein v717f (pdapp) transgenic mouse. J Neurosci. 1997. 17:7053–7059.
19. Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, Hyslop P, Johnstone EM, Little SP, Cummins DJ, Piccardo P, Ghetti B, Paul SM. Lack of apolipoprotein e dramatically reduces amyloid beta-peptide deposition. Nat Genet. 1997. 17:263–264.
20. Morimoto K, Yoshimi K, Tonohiro T, Yamada N, Oda T, Kaneko I. Co-injection of beta-amyloid with ibotenic acid induces synergistic loss of rat hippocampal neurons. Neuroscience. 1998. 84:479–487.
21. Nitta A, Fukuta T, Hasegawa T, Nabeshima T. Continuous infusion of beta-amyloid protein into the rat cerebral ventricle induces learning impairment and neuronal and morphological degeneration. Jpn J Pharmacol. 1997. 73:51–57.
22. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, Guido T, Hagopian S, Johnson-Wood K, Khan K, Lee M, Leibowitz P, Lieberburg I, Little S, Masliah E, McConlogue L, Montoya-Zavala M, Mucke L, Paganini L, Penniman E, Power M, Schenk D, Seubert P, Snyder B, Soriano F, Tan H, Vitale J, Wadsworth S, Wolozin B, Zhao J. Alzheimer-type neuropathology in transgenic mice overexpressing v717f b-amyloid precursor protein. Nature. 1995. 373:523–527.
23. Irizarry MC, McNamara M, Fedorchak K, Hsiao K, Hyman BT. Appsw transgenic mice develop age-related a beta deposits and neuropil abnormalities, but no neuronal loss in ca1. J Neuropathol Exp Neurol. 1997. 56:965–973.
24. Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM. Microglial response to amyloid plaques in appsw transgenic mice. Am J Pathol. 1998. 152:307–317.
25. Pappolla MA, Chyan YJ, Omar RA, Hsiao K, Perry G, Smith MA, Bozner P. Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo. Am J Pathol. 1998. 152:871–877.
26. Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Burki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B. Two amyloid precursor protein transgenic mouse models with alzheimer disease-like pathology. Proc Natl Acad Sci U S A. 1997. 94:13287–13292.
27. Calhoun ME, Wiederhold KH, Abramowski D, Phinney AL, Probst A, Sturchler-Pierrat C, Staufenbiel M, Sommer B, Jucker M. Neuron loss in app transgenic mice. Nature. 1998. 395:755–756.
28. Wang JZ, Gong CX, Zaidi T, Grundke-Iqbal I, Iqbal K. Dephosphorylation of alzheimer paired helical filaments by protein phosphatase-2a and -2b. J Biol Chem. 1995. 270:4854–4860.
29. Arendt T, Holzer M, Fruth R, Bruckner MK, Gartner U. Paired helical filament-like phosphorylation of tau, deposition of beta/a4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2a. Neuroscience. 1995. 69:691–698.
30. Gotz J, Probst A, Spillantini MG, Schafer T, Jakes R, Burki K, Goedert M. Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J. 1995. 14:1304–1313.
31. Brownlees J, Irving NG, Brion JP, Gibb BJ, Wagner U, Woodgett J, Miller CC. Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3beta transgenes. Neuroreport. 1997. 8:3251–3255.
32. Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George, Selkoe DJ. Mutant presenilins of alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med. 1997. 3:67–72.
33. Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grunberg J, Ueyama Y, Haass C, Ihara Y. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. J Neurochem. 1998. 71:313–322.
34. Chui DH, Tanahashi H, Ozawa K, Ikeda S, Checler F, Ueda O, Suzuki H, Araki W, Inoue H, Shirotani K, Takahashi K, Gallyas F, Tabira T. Transgenic mice with alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nat Med. 1999. 5:560–564.
35. Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron. 1997. 19:939–945.
36. Holcomb LA, Gordon MN, Jantzen P, Hsiao K, Duff K, Morgan D. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits. Behav Genet. 1999. 29:177–185.
37. Zhang W, Johnson BR, Suri DE, Martinez J, Bjornsson TD. Immunohistochemical demonstration of tissue transglutaminase in amyloid plaques. Acta Neuropathol. 1998. 96:395–400.
38. Cras P, van Harskamp F, Hendriks L, Ceuterick C, van Duijn CM, Stefanko SZ, Hofman A, Kros JM, Van Broeckhoven C, Martin JJ. Presenile alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the app 692ala-->gly mutation. Acta Neuropathol. 1998. 96:253–260.
39. Funato H, Yoshimura M, Yamazaki T, Saido TC, Ito Y, Yokofujita J, Okeda R, Ihara Y. Astrocytes containing amyloid beta-protein (abeta)-positive granules are associated with abeta40-positive diffuse plaques in the aged human brain. Am J Pathol. 1998. 152:983–992.
40. Beauchemin D, Kisilevsky R. A method based on icp-ms for the analysis of alzheimer's amyloid plaques. Anal Chem. 1998. 70:1026–1029.
41. McBride PA, Wilson MI, Eikelenboom P, Tunstall A, Bruce ME. Heparan sulfate proteoglycan is associated with amyloid plaques and neuroanatomically targeted prp pathology throughout the incubation period of scrapie-infected mice. Exp Neurol. 1998. 149:447–454.
42. Moechars D, Gilis M, Kuiperi C, Laenen I, Van Leuven F. Aggressive behaviour in transgenic mice expressing app is alleviated by serotonergic drugs. Neuroreport. 1998. 9:3561–3564.
43. Nichols A, Martinou I, Maundrell K, Martinou JC. The p75 neurotrophin receptor: effects on neuron survival in vitro and interaction with death domain-containing adaptor proteins. Apoptosis. 1998. 3:289–294.
44. Trojanowski JQ, Goedert M, Iwatsubo T, Lee VM. Fatal attractions: abnormal protein aggregation and neuron death in parkinson's disease and lewy body dementia. Cell Death Differ. 1998. 5:832–837.
45. Kurumatani T, Kudo T, Ikura Y, Takeda M. White matter changes in the gerbil brain under chronic cerebral hypoperfusion. Stroke. 1998. 29:1058–1062.
46. Nishio K, Ihara M, Yamasaki N, Kalaria RN, Maki T, Fujita Y, Ito H, Oishi N, Fukuyama H, Miyakawa T, Takahashi R, Tomimoto H. A mouse model characterizing features of vascular dementia with hippocampal atrophy. Stroke. 2010. 41:1278–1284.
47. Shibata M, Yamasaki N, Miyakawa T, Kalaria RN, Fujita Y, Ohtani R, Ihara M, Takahashi R, Tomimoto H. Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion. Stroke. 2007. 38:2826–2832.
48. Yoshizaki K, Adachi K, Kataoka S, Watanabe A, Tabira T, Takahashi K, Wakita H. Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice. Exp Neurol. 2008. 210:585–591.
49. Hainsworth AH, Markus HS. Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review. J Cereb Blood Flow Metab. 2008. 28:1877–1891.
50. Joutel A, Monet-Lepretre M, Gosele C, Baron-Menguy C, Hammes A, Schmidt S, Lemaire-Carrette B, Domenga V, Schedl A, Lacombe P, Hubner N. Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease. J Clin Invest. 2010. 120:433–445.
51. Kitamura N, Araya R, Kudoh M, Kishida H, Kimura T, Murayama M, Takashima A, Sakamaki Y, Hashikawa T, Ito S, Ohtsuki S, Terasaki T, Wess J, Yamada M. Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency. PLoS One. 2009. 4:e5159.
52. Araya R, Noguchi T, Yuhki M, Kitamura N, Higuchi M, Saido TC, Seki K, Itohara S, Kawano M, Tanemura K, Takashima A, Yamada K, Kondoh Y, Kanno I, Wess J, Yamada M. Loss of m5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice. Neurobiol Dis. 2006. 24:334–344.